Koga Michiaki
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine.
Brain Nerve. 2015 Nov;67(11):1313-20. doi: 10.11477/mf.1416200301.
Guillain-Barré syndrome can be classified into several phenotypes according to the type of predominantly disturbed nerve fibers, distribution of muscular weakness, and electrophysiological and pathological findings. Although several regional variants including Fisher syndrome and pharyngeal-cervical-brachial weakness were initially reported in Western researchers, many labor-intensive studies by Japanese researchers have significantly contributed to defining and highlighting these variants. This review summarizes the several regional variants of Guillain-Barré syndrome while highlighting the substantial contributions made by Japanese investigators. Furthermore, a new regional variant named "distal limb weakness" is proposed, in which regional weakness of hands and feet is observed throughout the disease course. It is considered a mild phenotype of acute axonal motor neuropathy after Campylobacter jejuni enteritis.
格林-巴利综合征可根据主要受累神经纤维的类型、肌无力的分布以及电生理和病理结果分为几种表型。尽管包括费舍尔综合征和咽-颈-臂肌无力在内的几种区域性变异最初是由西方研究人员报道的，但日本研究人员进行的许多劳动密集型研究对定义和突出这些变异做出了重大贡献。本综述总结了格林-巴利综合征的几种区域性变异，同时强调了日本研究人员所做的重要贡献。此外，还提出了一种名为“肢体远端无力”的新的区域性变异，在整个病程中均观察到手和脚的区域性无力。它被认为是空肠弯曲菌肠炎后急性轴索性运动神经病的一种轻型表型。
