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[吉兰-巴雷综合征中的神经生理学]

[Neurophysiology in Guillain-Barré syndrome].

作者信息

Kokubun Norito

机构信息

Department of Neurology, Dokkyo Medical University.

出版信息

Brain Nerve. 2015 Nov;67(11):1321-8. doi: 10.11477/mf.1416200302.

Abstract

The electrodiagnostic features for the demyelinating and axonal subtypes of Guillain-Barré syndrome (GBS) were described. In the early stage of demyelinating GBS, the most prominent neurophysiologic feature is the patchy demyelination in the peripheral nerves. Conduction slowing presents in the clinical recovery stage, which indicates the conduction slowing is due to mainly remyelination. Axonal GBS shows "reversible conduction failure", as well as primary axonal degeneration. "Reversible conduction failure" is thought to be the most common cause of the underestimation of axonal GBS. The electrodiagnostic criteria for GBS subtypes should be revised based on the knowledge acquired in recent years.

摘要

描述了吉兰-巴雷综合征(GBS)脱髓鞘型和轴索性亚型的电诊断特征。在脱髓鞘型GBS的早期,最突出的神经生理特征是周围神经的散在性脱髓鞘。传导减慢出现在临床恢复阶段,这表明传导减慢主要是由于再髓鞘化所致。轴索性GBS表现为“可逆性传导阻滞”以及原发性轴索变性。“可逆性传导阻滞”被认为是轴索性GBS被低估的最常见原因。应根据近年来获得的知识修订GBS亚型的电诊断标准。

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