Mori Masahiro
Department of Neurology, Graduate School of Medicine, Chiba University.
Brain Nerve. 2015 Nov;67(11):1359-69. doi: 10.11477/mf.1416200306.
Guillain-Barré syndrome is classified into demyelinating type, acute inflammatory demyelinating polyneuropathy (AIDP) and axonal form, acute axonal motor neuropathy (AMAN). It has been clearly established that the target molecule for the former is a ganglioside. In contrast, despite years of effort, the target molecule for the latter has not been identified. Recently, molecules around the nodes of Ranvier have entered the spotlight, and "moesin" was reported to be a target molecule for cytomegalovirus associated-AIDP.
吉兰-巴雷综合征分为脱髓鞘型，即急性炎症性脱髓鞘性多发性神经病（AIDP）和轴索性，即急性轴索性运动神经病（AMAN）。前者的靶分子已明确为神经节苷脂。相比之下，尽管经过多年努力，后者的靶分子仍未被确定。最近，郎飞结周围的分子受到关注，据报道“埃兹蛋白”是巨细胞病毒相关AIDP的靶分子。
