Nomura Kyoichi
Department of Neurology, Saitama Medical Center.
Brain Nerve. 2015 Nov;67(11):1397-410. doi: 10.11477/mf.1416200312.
The treatment of Guillain-Barre syndromé (GBS) was mainly symptomatic until the 1950s, followed by corticosteroid treatment in the 1950s through 1960s. Plasma exchange (PE) was then performed during 1970s through the 1980s, after which intravenous immunoglobulin (IVIg) was performed in 1990s through the 2000s. The effectiveness of IVIg and PE has been established by randomized controlled trial(RCT). Recently, new treatments using biological products have been explored. In this paper, we summarize the development of the treatment of GBS.
直到20世纪50年代，格林-巴利综合征（GBS）的治疗主要是对症治疗，随后在20世纪50年代至60年代采用皮质类固醇治疗。20世纪70年代至80年代进行血浆置换（PE），之后在20世纪90年代至21世纪初进行静脉注射免疫球蛋白（IVIg）。IVIg和PE的有效性已通过随机对照试验（RCT）得到证实。最近，人们探索了使用生物制品的新疗法。在本文中，我们总结了GBS治疗方法的发展历程。
