Bolondi L, Li Bassi S, Gaiani S, Santi V, Gullo L, Barbara L
Department of Medicine and Gastroenterology, University of Bologna, Italy.
Dig Dis Sci. 1989 Jun;34(6):834-40. doi: 10.1007/BF01540267.
In the present study we compared sonographic measurements of the main pancreatic duct (MPD) following maximal secretin stimulation (75 CU intravenous in 1 min) in 15 chronic pancreatitis patients (CP) with those of 18 normal control subjects. The mean caliber of the main pancreatic duct was 1.2 +/- 0.4 mm in controls and 1.8 +/- 0.9 in patients with chronic pancreatitis (P less than 0.025). In the control group a dilatation of the duct with a peak at the third minute was found. In patients with chronic pancreatitis a flatter profile of the response curve with a slower increase and inconstant return to basal values was found. A statistically significant difference was found between absolute variations of MPD caliber over basal values (1.7 +/- 1.06 in controls vs 0.8 +/- 0.69 in CP, P less than 0.005) and the dilatation index [(Dmax - D)/D] (1.31 +/- 0.6 in controls vs 0.66 +/- 0.69 in CP, P less than 0.005). The mean percent increase at the third minute was 131% in control subjects vs 53% of patients with CP (P less than 0.0005). In the five cases of CP showing a caliber increase greater than 100%, a persistent dilatation (100-200%) was found 15 min after secretin administration. At this time, the mean percent increase over basal value in controls was 25%.(ABSTRACT TRUNCATED AT 250 WORDS)
在本研究中，我们比较了15例慢性胰腺炎患者（CP）和18名正常对照者在最大剂量促胰液素刺激（1分钟内静脉注射75单位）后主胰管（MPD）的超声测量结果。对照组主胰管的平均管径为1.2±0.4毫米，慢性胰腺炎患者为1.8±0.9毫米（P<0.025）。在对照组中，发现胰管在第三分钟出现峰值扩张。在慢性胰腺炎患者中，发现反应曲线较为平缓，上升较慢且恢复至基础值不稳定。主胰管管径相对于基础值的绝对变化（对照组为1.7±1.06，慢性胰腺炎患者为0.8±0.69，P<0.005）以及扩张指数[（Dmax - D）/D]（对照组为1.31±0.6，慢性胰腺炎患者为0.66±0.69，P<0.005）存在统计学显著差异。第三分钟时，对照者的平均增加百分比为131%，而慢性胰腺炎患者为53%（P<0.0005）。在5例主胰管管径增加超过100%的慢性胰腺炎患者中，促胰液素给药15分钟后发现持续扩张（100 - 200%）。此时，对照组相对于基础值的平均增加百分比为25%。（摘要截短至250字）
