Khan Abdul Rehman, Awan Fazli Rabbi, Najam Syeda Sadia, Islam Mehboob, Siddique Tehmina, Zain Maryam
Biochemistry section,Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Diabetes and Cardio-Metabolic Disorder (D&C-MD) Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Diabetes and Cardio-Metabolic Disorder (D&C-MD) Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
J Pak Med Assoc. 2015 Nov;65(11):1182-5.
To investigate a correlation between serum alkaline phosphatase level and body mass index in human subjects.
The comparative cross-sectional study was carried out at the National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan, from April 2012 to June 2013. Blood serum alkaline phosphatase levels were estimated and the subjects were divided into three sub-groups on the basis of their body mass.
normal weight (<25kg/m2), overweight (25-27kg/m2) and obese (>27kg/m2) subjects. The serum samples were used for the estimation of clinically important biochemical parameters, using commercial kits on clinical chemistry analyser.
Of the 197 subjects, 97(49%) were obese and 100(51%) were non-obese. The serum alkaline phosphatase level increased in obese (214±6.4 IU/L) compared to the non-obese subjects (184.5±5 IU/L). Furthermore, a significant linear relationship (r=0.3;p-0.0001) was found between serum alkaline phosphatase and body mass index. Other biochemical variables were not correlated to the body mass index.
Over activity and higher amounts of alkaline phosphatase were linked to the development of obesity.
研究人类受试者血清碱性磷酸酶水平与体重指数之间的相关性。
2012年4月至2013年6月在巴基斯坦费萨拉巴德国家生物技术和基因工程研究所开展了一项比较性横断面研究。对血清碱性磷酸酶水平进行了测定，并根据受试者的体重将其分为三个亚组。
正常体重（<25kg/m²）、超重（25 - 27kg/m²）和肥胖（>27kg/m²）受试者。使用临床化学分析仪上的商用试剂盒，对血清样本进行具有临床重要意义的生化参数测定。
197名受试者中，97名（49%）为肥胖者，100名（51%）为非肥胖者。与非肥胖受试者（184.5±5 IU/L）相比，肥胖者（214±6.4 IU/L）的血清碱性磷酸酶水平升高。此外，血清碱性磷酸酶与体重指数之间存在显著的线性关系（r = 0.3；p = 0.0001）。其他生化变量与体重指数无关。
碱性磷酸酶活性过高和含量过高与肥胖的发生有关。
