Lyu Yuebin, Yin Zhaoxue, Luo Jiesi, Shi Xiaoming, Zeng Yi
Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Jul;36(7):682-6.
To explore the association between anemia and 3-year all-cause mortality among the oldest old people in longevity areas in China.
In August 2012, questionnaire survey, health examination and blood test were conducted among 929 old people aged ≥ 80 years in 7 longevity areas in China, who were included in Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2009. Cox regression model was used to evaluate the association between anemia or different hemoglobin levels and mortality.
Among the 929 subjects, the prevalence of anemia was 49.6%, the main form of anemia was normocytic anemia. During the three year follow-up period, a total of 447 subjects died, the overall mortality was 49.8% (56.0% in subjects with anemia and 43.3% in subjects without anemia). Compared with the subjects without anemia, the mortality risk increased by 25% in the subjects with anemia after adjusting confounding factors (HR = 1.25, 95% CI: 1.03-1.52). Macrocytic anemia, simplex microcytic anemia and microcytic hypochromic anemia were all associated with the increased mortality in the oldest old people. Compared with the subjects with low hemoglobin concentration, the subjects with high hemoglobin concentration had a lower mortality risk, and the association was more obvious in women.
Anemia and low hemoglobin concentration were associated with higher mortality risk in the oldest old people in China, indicating the importance of anemia prevention and treatment among this population.
探讨中国长寿地区高龄老人贫血与3年全因死亡率之间的关联。
2012年8月，对纳入2009年中国老年健康长寿跟踪调查（CLHLS）的中国7个长寿地区的929名80岁及以上老年人进行问卷调查、健康检查和血液检测。采用Cox回归模型评估贫血或不同血红蛋白水平与死亡率之间的关联。
929名研究对象中，贫血患病率为49.6%，贫血的主要类型为正细胞性贫血。在三年随访期间，共有447名研究对象死亡，总死亡率为49.8%（贫血者为56.0%，非贫血者为43.3%）。调整混杂因素后，与非贫血者相比，贫血者的死亡风险增加了25%（HR = 1.25，95%CI：1.03 - 1.52）。大细胞性贫血、单纯小细胞性贫血和小细胞低色素性贫血均与高龄老人死亡率增加有关。与血红蛋白浓度低的研究对象相比，血红蛋白浓度高的研究对象死亡风险较低，且这种关联在女性中更为明显。
贫血和低血红蛋白浓度与中国高龄老人较高的死亡风险相关，提示该人群中贫血防治的重要性。
