[中国男男性行为人群HIV感染率及危险因素的Meta分析]

[Meta-analysis of HIV infection incidence and risk factors among men who have sex with men in China].

作者信息

Feng Yibing, Bu Kai, Li Meng, Zhang Xiayan, Jin Shanshan, Wang Lu

机构信息

National Center for STD/AIDS Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

National Center for STD/AIDS Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Email:

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Jul;36(7):752-8.

PMID:26564708

Abstract

OBJECTIVE

To understand the incidence of HIV infection among men who have sex with men (MSM) in China.

METHODS

Meta-analysis was performed to systematically and quantitatively review all the original research papers and reports published during 2010-2015 on the incidence of HIV infection among MSM in China. Pooled incidence, pooled hazard ratios, publication bias, heterogeneity and sensitivity analysis for those studies were calculated or analyzed by using Stata 12.0 software.

RESULTS

A total of 24 studies were analyzed. Pooled incidence of HIV infection among MSM in China was 5.0/100 person year; Based on HIV case report, severe epidemic areas had higher HIV incidence than other areas (4.9/100 person year vs. 3.4/100 person year). Low education level (HR = 1.61, 95% CI: 1.21-2.15), syphilis prevalence (HR = 3.22, 95% CI: 2.21-4.70), unprotected anal sex (HR = 2.92, 95% CI: 1.51-5.63), minority ethnic group (HR = 4.01, 95% CI: 1.96-8.21), commercial sex (HR = 4.11, 95% CI: 1.47-11.46) and multiple sexual partners (HR = 2.31, 95% CI: 1.60-3.34) were the risk factors for HIV incidence.

CONCLUSION

Pooled incidence of HIV infection among MSM was 5.0% in China. Low education level, syphilis prevalence, unprotected anal sex, minority ethnic group, commercial sex and multiple sexual partners were the risk factors for HIV infection.

摘要

目的

了解中国男男性行为者（MSM）中艾滋病毒感染率。

方法

进行荟萃分析，以系统地、定量地回顾2010年至2015年期间发表的所有关于中国男男性行为者艾滋病毒感染率的原始研究论文和报告。使用Stata 12.0软件计算或分析这些研究的合并感染率、合并风险比、发表偏倚、异质性和敏感性分析。

结果

共分析了24项研究。中国男男性行为者艾滋病毒感染的合并感染率为5.0/100人年；根据艾滋病毒病例报告，严重流行地区的艾滋病毒感染率高于其他地区（4.9/100人年对3.4/100人年）。低教育水平（HR = 1.61，95%CI：1.21 - 2.15）、梅毒患病率（HR = 3.22，95%CI：2.21 - 4.70）、无保护肛交（HR = 2.92，95%CI：1.51 - 5.63）、少数民族（HR = 4.01，95%CI：1.96 - 8.21）、商业性行为（HR = 4.11，95%CI：1.47 - 11.46）和多个性伴侣（HR = 2.31，95%CI：1.60 - 3.34）是艾滋病毒感染率的危险因素。