北京一家三级医院中急性 HIV 感染者药物依从性的相关因素。
Factors Associated with Medication Adherence for People Living with Acute HIV Infection in a Tertiary Chinese Hospital in Beijing.
机构信息
Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Department of Nursing, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
出版信息
Biomed Res Int. 2021 Jan 5;2021:1078716. doi: 10.1155/2021/1078716. eCollection 2021.
Both the management and caregiving intervention of people living with HIV (PLWH), especially during acute HIV-1 infection, represent a public health issue and a form of social support. This current study analyzed the demographic and clinical factors associated with antiretroviral therapy (ART) adherence of PLWH from positive HIV diagnosis to ART initiation in a tertiary Chinese hospital in Beijing. A total of 200 participants diagnosed with acute HIV-1 infection were enrolled in this study. We collected demographic and clinical data by the use of a self-reported questionnaire. Bivariate and multivariate logistic regressions were used to determine associations between potential variables and outcomes. We found that medication adherence was impacted by years of ART and number of reminders (all < 0.05). In addition, medication adherence was associated with viral load at 48 weeks ( = 0.035). Future studies are needed to investigate effective interventions that could facilitate ART adherence.
艾滋病病毒感染者（PLWH）的管理和护理干预，特别是在急性 HIV-1 感染期间，既是一个公共卫生问题，也是一种社会支持形式。本研究分析了北京一家三级医院从 HIV 阳性诊断到开始抗逆转录病毒治疗（ART）期间与 PLWH 接受 ART 依从性相关的人口统计学和临床因素。本研究共纳入了 200 名诊断为急性 HIV-1 感染的参与者。我们通过使用自我报告问卷收集了人口统计学和临床数据。采用单变量和多变量逻辑回归来确定潜在变量与结果之间的关联。我们发现，药物依从性受到 ART 年限和提醒次数的影响（均<0.05）。此外，药物依从性与 48 周时的病毒载量有关（=0.035）。需要进一步研究以探讨有效的干预措施，以促进 ART 依从性。
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