• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

生命早期暴露于纤细梭菌会导致肺部免疫抑制。

Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression.

作者信息

Huang Fei, Qiao Hong-Mei, Yin Jia-Ning, Gao Yang, Ju Yang-Hua, Li Ya-Nan

机构信息

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China.

Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin, PR China.

出版信息

PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.

DOI:10.1371/journal.pone.0141717
PMID:26565810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4643994/
Abstract

INTRODUCTION

Low Clostridium leptum levels are a risk factor for the development of asthma. C. leptum deficiency exacerbates asthma; however, the impact of early-life C. leptum exposure on cesarean-delivered mice remains unclear. This study is to determine the effects of early-life C. leptum exposure on asthma development in infant mice.

METHODS

We exposed infant mice to C. leptum (fed-CL) and then induced asthma using the allergen ovalbumin (OVA).

RESULTS

Fed-CL increased regulatory T (Treg) cells in cesarean-delivered mice compared with vaginally delivered mice. Compared with OVA-exposed mice, mice exposed to C. leptum + OVA did not develop the typical asthma phenotype, which includes airway hyper-responsiveness, cell infiltration, and T helper cell subset (Th1, Th2, Th9, Th17) inflammation. Early-life C. leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th1, Th2, Th9, and Th17 cell responses.

CONCLUSION

These findings demonstrate a mechanism whereby C. leptum exposure modulates adaptive immunity and leads to failure to develop asthma upon OVA sensitization later in life.

摘要

引言

梭状芽孢杆菌水平低是哮喘发病的一个风险因素。梭状芽孢杆菌缺乏会加重哮喘；然而，生命早期接触梭状芽孢杆菌对剖宫产小鼠的影响仍不清楚。本研究旨在确定生命早期接触梭状芽孢杆菌对幼鼠哮喘发展的影响。

方法

我们将幼鼠暴露于梭状芽孢杆菌（喂食梭状芽孢杆菌组），然后用过敏原卵清蛋白（OVA）诱导哮喘。

结果

与经阴道分娩的小鼠相比，喂食梭状芽孢杆菌组增加了剖宫产小鼠体内的调节性T（Treg）细胞。与暴露于OVA的小鼠相比，暴露于梭状芽孢杆菌+OVA的小鼠未出现典型的哮喘表型，包括气道高反应性、细胞浸润和辅助性T细胞亚群（Th1、Th2、Th9、Th17）炎症。生命早期接触梭状芽孢杆菌会在肺部诱导免疫抑制环境，同时Treg细胞增加，从而抑制Th1、Th2、Th9和Th17细胞反应。

结论

这些发现证明了一种机制，即接触梭状芽孢杆菌可调节适应性免疫，并导致在生命后期OVA致敏时无法发生哮喘。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/3487c605eb27/pone.0141717.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/53cf231b4cc9/pone.0141717.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/f6fc2c6055af/pone.0141717.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/138a25498d03/pone.0141717.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/175bb5134d60/pone.0141717.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/3487c605eb27/pone.0141717.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/53cf231b4cc9/pone.0141717.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/f6fc2c6055af/pone.0141717.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/138a25498d03/pone.0141717.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/175bb5134d60/pone.0141717.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7704/4643994/3487c605eb27/pone.0141717.g005.jpg

相似文献

1
Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression.生命早期暴露于纤细梭菌会导致肺部免疫抑制。
PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
2
Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice.口服脆弱拟杆菌对小鼠调节性 T 细胞应答和过敏性气道炎症的影响。
Ann Allergy Asthma Immunol. 2012 Sep;109(3):201-7. doi: 10.1016/j.anai.2012.06.017. Epub 2012 Jul 17.
3
Intestine-derived Clostridium leptum induces murine tolerogenic dendritic cells and regulatory T cells in vitro.源自肠道的纤细梭菌在体外诱导小鼠耐受性树突状细胞和调节性T细胞。
Hum Immunol. 2014 Dec;75(12):1232-8. doi: 10.1016/j.humimm.2014.09.017. Epub 2014 Oct 6.
4
Bu-Shen-Yi-Qi formulae suppress chronic airway inflammation and regulate Th17/Treg imbalance in the murine ovalbumin asthma model.补肺益肾方抑制卵清蛋白哮喘模型小鼠气道慢性炎症及调节 Th17/Treg 失衡。
J Ethnopharmacol. 2015 Apr 22;164:368-77. doi: 10.1016/j.jep.2015.01.016. Epub 2015 Jan 24.
5
[Experimental study on role of endotoxin in induction of murine model of allergic asthma].[内毒素在诱导小鼠过敏性哮喘模型中的作用的实验研究]
Wei Sheng Yan Jiu. 2008 Jul;37(4):397-404.
6
Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression.生命早期暴露于燃烧产生的颗粒物会导致肺部免疫抑制。
Mucosal Immunol. 2014 May;7(3):694-704. doi: 10.1038/mi.2013.88. Epub 2013 Oct 30.
7
CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma.鼻内应用卵清蛋白诱导 CD4+CD25-mTGFβ+T 细胞转移耐受在哮喘治疗模型中的作用。
Int Immunol. 2011 Jan;23(1):17-27. doi: 10.1093/intimm/dxq453. Epub 2010 Dec 1.
8
Prior Bordetella pertussis infection modulates allergen priming and the severity of airway pathology in a murine model of allergic asthma.先前的百日咳博德特氏菌感染可调节变应原致敏以及变应性哮喘小鼠模型中气道病理的严重程度。
Clin Exp Allergy. 2004 Sep;34(9):1488-97. doi: 10.1111/j.1365-2222.2004.02042.x.
9
Schistosoma japonicum egg antigens stimulate CD4 CD25 T cells and modulate airway inflammation in a murine model of asthma.日本血吸虫卵抗原刺激CD4 CD25 T细胞并调节哮喘小鼠模型中的气道炎症。
Immunology. 2007 Jan;120(1):8-18. doi: 10.1111/j.1365-2567.2006.02472.x. Epub 2006 Oct 17.
10
The Effects of All-Trans Retinoic Acid on the Induction of Oral Tolerance in a Murine Model of Bronchial Asthma.全反式维甲酸对支气管哮喘小鼠模型口腔耐受诱导的影响。
Int Arch Allergy Immunol. 2015;167(3):167-76. doi: 10.1159/000437326. Epub 2015 Aug 20.

引用本文的文献

1
Explore Alteration of Lung and Gut Microbiota in a Murine Model of OVA-Induced Asthma Treated by CpG Oligodeoxynucleotides.探索经CpG寡脱氧核苷酸治疗的卵清蛋白诱导哮喘小鼠模型中肺和肠道微生物群的变化。
J Inflamm Res. 2025 Jan 11;18:445-461. doi: 10.2147/JIR.S487916. eCollection 2025.
2
Management of a pregnant woman with a large cervical polyp and moderate genital bleeding in the first trimester.处理一位孕早期宫颈有大息肉且有中等程度生殖道出血的孕妇。
BMJ Case Rep. 2024 Mar 5;17(3):e258163. doi: 10.1136/bcr-2023-258163.
3
The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients.

本文引用的文献

1
The role of the microbiome in immune cell development.微生物群落在免疫细胞发育中的作用。
Ann Allergy Asthma Immunol. 2014 Dec;113(6):593-8. doi: 10.1016/j.anai.2014.08.020.
2
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.自身免疫性疾病和炎症性疾病中的T细胞亚群及其标志性细胞因子。
Cytokine. 2015 Jul;74(1):5-17. doi: 10.1016/j.cyto.2014.09.011. Epub 2014 Oct 30.
3
Food allergy enhances allergic asthma in mice.食物过敏会加重小鼠的过敏性哮喘。
危重病中的肠-肺轴：微生物组构成可预测机械通气患者 28 天死亡率。
BMC Microbiol. 2023 Dec 18;23(1):399. doi: 10.1186/s12866-023-03078-3.
4
Th17 Cells, Glucocorticoid Resistance, and Depression.辅助性 T 细胞 17、糖皮质激素抵抗与抑郁
Cells. 2023 Nov 30;12(23):2749. doi: 10.3390/cells12232749.
5
Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema.短期食用葡萄可减轻紫外线引起的皮肤红斑。
Antioxidants (Basel). 2022 Nov 30;11(12):2372. doi: 10.3390/antiox11122372.
6
Fecal Microbiota Transplantation Controls Progression of Experimental Autoimmune Hepatitis in Mice by Modulating the TFR/TFH Immune Imbalance and Intestinal Microbiota Composition.粪便微生物群移植通过调节 TFR/TFH 免疫失衡和肠道微生物群组成控制实验性自身免疫性肝炎在小鼠中的进展。
Front Immunol. 2021 Nov 29;12:728723. doi: 10.3389/fimmu.2021.728723. eCollection 2021.
7
Maternal vitamin D deficiency impairs Treg and Breg responses in offspring mice and deteriorates allergic airway inflammation.母体维生素D缺乏会损害子代小鼠的调节性T细胞（Treg）和调节性B细胞（Breg）反应，并使过敏性气道炎症恶化。
Allergy Asthma Clin Immunol. 2020 Oct 14;16:89. doi: 10.1186/s13223-020-00487-1. eCollection 2020.
8
Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients.Graves 病患者肠道微生物组成的分子改变分析。
Int J Biol Sci. 2018 Sep 7;14(11):1558-1570. doi: 10.7150/ijbs.24151. eCollection 2018.
9
Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.Toll 样受体 4 介导的淋巴细胞失衡诱导 Nec 诱导的肺损伤。
Shock. 2019 Aug;52(2):215-223. doi: 10.1097/SHK.0000000000001255.
10
Pig Farmers' Homes Harbor More Diverse Airborne Bacterial Communities Than Pig Stables or Suburban Homes.与猪舍或郊区住宅相比，养猪农户的家中含有更多样化的空气传播细菌群落。
Front Microbiol. 2018 May 1;9:870. doi: 10.3389/fmicb.2018.00870. eCollection 2018.
Respir Res. 2014 Nov 30;15(1):142. doi: 10.1186/s12931-014-0142-x.
4
Gut microbiota: a source of novel tools to reduce the risk of human disease?肠道微生物群：降低人类疾病风险的新工具来源？
Pediatr Res. 2015 Jan;77(1-2):182-8. doi: 10.1038/pr.2014.173. Epub 2014 Oct 21.
5
Intestine-derived Clostridium leptum induces murine tolerogenic dendritic cells and regulatory T cells in vitro.源自肠道的纤细梭菌在体外诱导小鼠耐受性树突状细胞和调节性T细胞。
Hum Immunol. 2014 Dec;75(12):1232-8. doi: 10.1016/j.humimm.2014.09.017. Epub 2014 Oct 6.
6
Graphene oxide attenuates Th2-type immune responses, but augments airway remodeling and hyperresponsiveness in a murine model of asthma.氧化石墨烯可减弱Th2型免疫反应，但在哮喘小鼠模型中会加剧气道重塑和高反应性。
ACS Nano. 2014 Jun 24;8(6):5585-99. doi: 10.1021/nn406454u. Epub 2014 May 23.
7
A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice.一种新型靶向胰腺β细胞的双特异性抗体（BsAb）可预防 NOD 小鼠发生 1 型糖尿病。
Clin Immunol. 2014 Jul;153(1):187-98. doi: 10.1016/j.clim.2014.04.014. Epub 2014 May 2.
8
Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay.采用新型高通量筛选检测法鉴定广谱抗严重急性呼吸综合征冠状病毒和埃博拉、亨德拉及尼帕病毒的小分子抗病毒药物。
J Virol. 2014 Apr;88(8):4353-65. doi: 10.1128/JVI.03050-13. Epub 2014 Feb 5.
9
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.通过从人类微生物群中合理选择的共生梭菌混合物诱导 Treg。
Nature. 2013 Aug 8;500(7461):232-6. doi: 10.1038/nature12331. Epub 2013 Jul 10.
10
The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.IL-7 与其受体结合在类风湿关节炎和胶原诱导性关节炎的髓系细胞中的新作用。
J Immunol. 2013 May 15;190(10):5256-66. doi: 10.4049/jimmunol.1201675. Epub 2013 Apr 19.