日本一家儿童医院中，儿童肝移植前后接种无细胞百日咳疫苗后疫苗失败率较高。
High rate of vaccine failure after administration of acellular pertussis vaccine pre- and post-liver transplantation in children at a children's hospital in Japan.
作者信息
Ito K, Kasahara M, Saitoh A, Honda H, Miyairi I
机构信息
Division of Pediatric Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan.
Department of Infectious Diseases, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
出版信息
Transpl Infect Dis. 2016 Feb;18(1):150-4. doi: 10.1111/tid.12484. Epub 2016 Jan 30.
We assessed the serological response to pertussis vaccines administered pre- and post-liver transplantation in 58 pediatric patients at a children's hospital in Japan. A high rate of pertussis vaccine failure was observed, 44.8% against the pertussis toxin and 69.0% against filamentous hemagglutinin, with no difference in the seropositivity rate with respect to the timing of the vaccination during the peritransplant period.
我们评估了日本一家儿童医院58例儿科患者肝移植前后接种百日咳疫苗的血清学反应。观察到百日咳疫苗的失败率很高，针对百日咳毒素的失败率为44.8%，针对丝状血凝素的失败率为69.0%，围移植期接种疫苗的时间对血清阳性率没有影响。
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