Huntington Justin T, Tang Xing, Kent Lindsey N, Schmidt Carl R, Leone Gustavo
Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, Columbus, Ohio.
J Cell Physiol. 2016 Jul;231(7):1438-49. doi: 10.1002/jcp.25242. Epub 2016 Feb 2.
Uncoordinated cell growth is one of the fundamental concepts in carcinogenesis and occurs secondary to dysregulation of the cell cycle. The E2Fs are a large family of transcription factors and are key regulators of the cell cycle. The activation of E2Fs is intimately regulated by retinoblastoma 1 (RB1). The RB pathway has been implicated in almost every human malignancy. Recently there have been exciting developments in the E2F field using animal models to better understand the role of E2Fs in vivo. Genetic mouse models have proven essential in implicating E2Fs in hepatocellular carcinoma (HCC) and liver disease. In this review, the general structure and function of E2Fs as well as the role for E2Fs in the development of HCC and liver disease is evaluated. Specifically, what is known about E2Fs in human disease is explored in depth, and future directions are discussed.
不协调的细胞生长是致癌作用的基本概念之一，继发于细胞周期失调。E2F是一大类转录因子，是细胞周期的关键调节因子。E2F的激活受视网膜母细胞瘤1（RB1）密切调控。RB通路几乎涉及每一种人类恶性肿瘤。最近，利用动物模型在E2F领域取得了令人兴奋的进展，以更好地了解E2F在体内的作用。基因小鼠模型已被证明在阐明E2F在肝细胞癌（HCC）和肝脏疾病中的作用方面至关重要。在本综述中，评估了E2F的一般结构和功能以及E2F在HCC和肝脏疾病发展中的作用。具体而言，深入探讨了人类疾病中关于E2F的已知情况，并讨论了未来的方向。
