Liu Hui, Yang Mei, Dong Zhiwei
Department of Gastroenterology, Second Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Department of General Surgery, Air Force Medical Center, PLA, Beijing, People's Republic of China.
Int J Gen Med. 2022 Apr 13;15:4017-4027. doi: 10.2147/IJGM.S363679. eCollection 2022.
Heat shock proteins (HSPs) play important roles in oncogenesis and malignant progression. HSPB11 is highly expressed in many malignant tumors, but research on its role in hepatocellular carcinoma (HCC) is insufficient.
A comprehensive analysis of HSPB11 in HCC was performed based on data of patients with HCC and those from online public databases.
HSPB11 was overexpressed in HCC, with a high discrimination ability between tumor and normal tissues (area under the curve =0.923). HSPB11 overexpression correlated with advanced tumor stage, poorer tumor differentiation, and worse prognosis and was an independent risk factor for HCC prognosis. The nomogram and calibration models composed of HSPB11, T stage, and M stage had good abilities to predict the 1-, 3-, and 5-year survival rates of patients. HSPB11 was determined to be involved in multiple oncogenic processes, including cell cycle checkpoints, the G2M checkpoint, E2F targets, Rho GTPases, and KRAS signaling. HSPB11 expression was related to immune cell infiltration, especially that of Th2 cells and dendritic cells.
HSPB11 is involved in oncogenesis and immune regulation in HCC and is a potential prognostic biomarker and therapeutic target.
热休克蛋白（HSPs）在肿瘤发生和恶性进展中起重要作用。HSPB11在许多恶性肿瘤中高表达，但对其在肝细胞癌（HCC）中的作用研究不足。
基于HCC患者的数据及在线公共数据库的数据，对HCC中的HSPB11进行综合分析。
HSPB11在HCC中过表达，在肿瘤组织与正常组织之间具有较高的鉴别能力（曲线下面积=0.923）。HSPB11过表达与肿瘤晚期、较差的肿瘤分化及更差的预后相关，是HCC预后的独立危险因素。由HSPB11、T分期和M分期组成的列线图和校准模型对患者1年、3年和5年生存率具有良好的预测能力。HSPB11被确定参与多个致癌过程，包括细胞周期检查点、G2M检查点、E2F靶标、Rho GTP酶和KRAS信号传导。HSPB11表达与免疫细胞浸润有关，尤其是Th2细胞和树突状细胞的浸润。
HSPB11参与HCC的肿瘤发生和免疫调节，是一种潜在的预后生物标志物和治疗靶点。
