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本文引用的文献

1
Committee Opinion No. 640: Cell-Free DNA Screening For Fetal Aneuploidy.第640号委员会意见：游离DNA筛查胎儿非整倍体。
Obstet Gynecol. 2015 Sep;126(3):e31-e37. doi: 10.1097/AOG.0000000000001051.
2
Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis.染色体异常筛查委员会代表国际产前诊断学会理事会发表的立场声明。
Prenat Diagn. 2015 Aug;35(8):725-34. doi: 10.1002/pd.4608. Epub 2015 Jun 4.
3
Cell-free DNA analysis for noninvasive examination of trisomy.游离 DNA 分析用于非侵入性的三体检查。
N Engl J Med. 2015 Apr 23;372(17):1589-97. doi: 10.1056/NEJMoa1407349. Epub 2015 Apr 1.
4
Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States.美国唐氏综合征活产、自然流产及选择性终止妊娠的估计数据。
Am J Med Genet A. 2015 Apr;167A(4):756-67. doi: 10.1002/ajmg.a.37001.
5
Uptake of noninvasive prenatal testing at a large academic referral center.大型学术转诊中心对无创产前检测的接受情况。
Am J Obstet Gynecol. 2014 Dec;211(6):651.e1-7. doi: 10.1016/j.ajog.2014.06.038. Epub 2014 Jun 19.
6
Current status of prenatal diagnosis in Cuba: causes of low prevalence of Down syndrome.古巴产前诊断的现状：唐氏综合征低患病率的原因
Prenat Diagn. 2014 Nov;34(11):1049-54. doi: 10.1002/pd.4421. Epub 2014 Jun 20.
7
Noninvasive prenatal testing goes global.无创性产前检测走向全球化。
Sci Transl Med. 2014 Apr 9;6(231):231fs15. doi: 10.1126/scitranslmed.3008704.
8
Demographic and experiential correlates of public attitudes towards cell-free fetal DNA screening.公众对游离胎儿DNA筛查态度的人口统计学和经验相关因素。
J Genet Couns. 2014 Dec;23(6):957-67. doi: 10.1007/s10897-014-9704-9. Epub 2014 Apr 9.
9
A single center's experience with noninvasive prenatal testing.单中心无创产前检测的经验
Genet Med. 2014 Sep;16(9):681-7. doi: 10.1038/gim.2014.20. Epub 2014 Mar 27.
10
Attitudes of pregnant women and male partners towards non-invasive prenatal testing and widening the scope of prenatal screening.孕妇及其男性伴侣对无创产前检测和扩大产前筛查范围的态度。
Eur J Hum Genet. 2014 Dec;22(12):1345-50. doi: 10.1038/ejhg.2014.32. Epub 2014 Mar 19.

“这一终身承诺”：公众对残疾及无创产前基因检测的认知

"This lifetime commitment": Public conceptions of disability and noninvasive prenatal genetic screening.

作者信息

Steinbach Rosemary J, Allyse Megan, Michie Marsha, Liu Emily Y, Cho Mildred K

机构信息

Stanford Center for Biomedical Ethics, Stanford, California.

Biomedical Ethics Research Program and Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

出版信息

Am J Med Genet A. 2016 Feb;170A(2):363-374. doi: 10.1002/ajmg.a.37459. Epub 2015 Nov 14.

DOI:10.1002/ajmg.a.37459
PMID:26566970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4948186/
Abstract

Recently, new noninvasive prenatal genetic screening technologies for Down syndrome and other genetic conditions have become commercially available. Unique characteristics of these screening tests have reignited long-standing concerns about prenatal testing for intellectual and developmental disabilities. We conducted a web-based survey of a sample of the US public to examine how attitudes towards disability inform views of prenatal testing in the context of these rapidly advancing prenatal genetic screening technologies. Regardless of opinion toward disability, the majority of respondents supported both the availability of screening and the decision to continue a pregnancy positive for aneuploidy. Individuals rationalized their support with various conceptions of disability; complications of the expressivist argument and other concerns from the disability literature were manifested in many responses analyzed.

摘要

最近，用于唐氏综合征和其他遗传疾病的新型非侵入性产前基因筛查技术已投入商业使用。这些筛查测试的独特特性再次引发了人们对智力和发育障碍产前检测的长期担忧。我们对美国公众样本进行了一项基于网络的调查，以研究在这些快速发展的产前基因筛查技术背景下，对残疾的态度如何影响对产前检测的看法。无论对残疾持何种看法，大多数受访者都支持进行筛查以及继续怀有非整倍体检测呈阳性胎儿的决定。个体用各种残疾观念来合理化他们的支持；在许多分析的回答中都体现了表现主义论点的复杂性以及残疾文献中的其他担忧。