Beach Steven R H, Dogan Meeshanthini V, Lei Man-Kit, Cutrona Carolyn E, Gerrard Meg, Gibbons Frederick X, Simons Ronald L, Brody Gene H, Philibert Robert A
Department of Psychology, University of Georgia, Athens, Georgia.
Center for Family Research, University of Georgia, Athens, Georgia.
J Am Geriatr Soc. 2015 Dec;63(12):2519-2525. doi: 10.1111/jgs.13830. Epub 2015 Nov 14.
To examine the effect of the relationship between alcohol and cigarette consumption on biological aging using deoxyribonucleic acid methylation-based indices.
Hierarchical linear regression modeling followed by fitting of higher-order effects.
Longitudinal studies of aging and the effect of psychosocial stress.
Participants in two ethnically informative cohorts (n = 656 white, n = 180 black).
Deviation of biological age from chronological age as a result of smoking and alcohol consumption.
Greater cigarette consumption was associated with accelerated biological aging, with strong effects evident at even low levels of exposure. In contrast, alcohol consumption was associated with a mixed effect on biological aging and pronounced nonlinear effects. At low and heavy levels of alcohol consumption, there was accelerated biological aging, whereas at intermediate levels of consumption there was a relative decelerating effect. The decelerating effects of alcohol were particularly notable at loci for which methylation increased with age.
These data support prior epidemiological studies indicating that moderate alcohol use is associated with healthy aging, but we urge caution in interpreting these results. Conversely, smoking has strong negative effects at all levels of consumption. These results also support the use of methylomic indices as a tool for assessing the impact of lifestyle on aging.
使用基于脱氧核糖核酸甲基化的指标来研究酒精与香烟消费之间的关系对生物衰老的影响。
分层线性回归建模，随后拟合高阶效应。
衰老的纵向研究以及心理社会压力的影响。
来自两个具有种族信息的队列的参与者（n = 656名白人，n = 180名黑人）。
吸烟和饮酒导致的生物年龄与实际年龄的偏差。
吸烟量增加与生物衰老加速相关，即使在低暴露水平下也有明显的强烈影响。相比之下，饮酒与生物衰老的混合效应以及明显的非线性效应相关。在低饮酒量和高饮酒量水平下，生物衰老加速，而在中等饮酒量水平下则有相对减速效应。酒精的减速效应在甲基化随年龄增加的位点尤为明显。
这些数据支持先前的流行病学研究，表明适度饮酒与健康衰老相关，但我们在解释这些结果时需谨慎。相反，吸烟在所有消费水平上都有强烈的负面影响。这些结果也支持使用甲基化组指标作为评估生活方式对衰老影响的工具。
