Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey.
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
J Infect Dis. 2024 Jun 14;229(6):1803-1811. doi: 10.1093/infdis/jiae016.
The relationship between accelerated epigenetic aging and musculoskeletal outcomes in women with HIV (WWH) has not been studied.
We measured DNA methylation age using the Infinium MethylationEPIC BeadChip in a cohort from the Women's Interagency HIV Study (n = 190) with measures of bone mineral density (BMD) and physical function. We estimated 6 biomarkers of epigenetic aging-epigenetic age acceleration (EAA), extrinsic EAA, intrinsic EAA, GrimAge, PhenoAge, and DNA methylation-estimated telomere length-and evaluated associations of epigenetic aging measures with BMD and physical function. We also performed epigenome-wide association studies to examine associations of DNA methylation signatures with BMD and physical function.
This study included 118 WWH (mean age, 49.7 years; 69% Black) and 72 without HIV (mean age, 48.9 years; 69% Black). WWH had higher EAA (mean ± SD, 1.44 ± 5.36 vs -1.88 ± 5.07; P < .001) and lower DNA methylation-estimated telomere length (7.13 ± 0.31 vs 7.34 ± 0.23, P < .001) than women without HIV. There were no significant associations between accelerated epigenetic aging and BMD. Rather, measures of accelerated epigenetic aging were associated with lower physical function.
Accelerated epigenetic aging was observed in WWH as compared with women without HIV and was associated with lower physical function in both groups.
HIV 女性（WWH）的加速表观遗传衰老与肌肉骨骼结局之间的关系尚未得到研究。
我们使用 Infinium MethylationEPIC BeadChip 在 Women's Interagency HIV Study 队列中（n=190）测量了 DNA 甲基化年龄，该队列具有骨密度（BMD）和身体功能的测量值。我们估计了 6 种表观遗传衰老标志物-表观遗传年龄加速（EAA）、外在 EAA、内在 EAA、GrimAge、PhenoAge 和 DNA 甲基化估计的端粒长度，并评估了表观遗传衰老指标与 BMD 和身体功能的关联。我们还进行了全基因组关联研究，以检查 DNA 甲基化特征与 BMD 和身体功能的关联。
本研究包括 118 名 WWH（平均年龄 49.7 岁；69%为黑人）和 72 名无 HIV 感染者（平均年龄 48.9 岁；69%为黑人）。与无 HIV 的女性相比，WWH 的 EAA 更高（平均±SD，1.44±5.36 与-1.88±5.07；P<.001），DNA 甲基化估计的端粒长度更短（7.13±0.31 与 7.34±0.23，P<.001）。加速的表观遗传衰老与 BMD 之间没有显著关联。相反，加速的表观遗传衰老指标与较低的身体功能有关。
与无 HIV 的女性相比，WWH 中观察到加速的表观遗传衰老，并且在两组中都与较低的身体功能有关。
