低温诱导的脑内细胞保护机制。
Mechanisms of hypothermia-induced cell protection in the brain.
作者信息
Schmitt Katharina Rose Luise, Tong Giang, Berger Felix
机构信息
Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Department of Pediatric Cardiology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.
出版信息
Mol Cell Pediatr. 2014 Dec;1(1):7. doi: 10.1186/s40348-014-0007-x. Epub 2014 Dec 1.
Abstract
Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention.
摘要
治疗性低温是一种有效的细胞保护剂，也是一种有前景的干预措施，已证明可改善心脏骤停和新生儿缺氧缺血后患者的预后。然而，尽管我们有临床和实验经验，但治疗性低温的保护性分子机制仍有待阐明。因此，在本简要综述中，我们将讨论治疗性低温的临床证据和分子机制，以便对这一有前景的干预措施有更深入的了解。
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