Rincon Sabatino Samantha, Rivero Andrea, Sangaletti Rachele, Dietrich W Dalton, Hoffer Michael E, King Curtis S, Rajguru Suhrud M
Department of Biomedical Engineering, University of Miami, Coral Gables, FL, United States.
The Miami Project to Cure Paralysis, University of Miami, Coral Gables, FL, United States.
Front Neurosci. 2024 Jan 16;17:1296458. doi: 10.3389/fnins.2023.1296458. eCollection 2023.
Exposure to occupational or recreational loud noise activates multiple biological regulatory circuits and damages the cochlea, causing permanent changes in hearing sensitivity. Currently, no effective clinical therapy is available for the treatment or mitigation of noise-induced hearing loss (NIHL). Here, we describe an application of localized and non-invasive therapeutic hypothermia and targeted temperature management of the inner ear to prevent NIHL.
We developed a custom-designed cooling neck collar to reduce the temperature of the inner ear by 3-4°C post-injury to deliver mild therapeutic hypothermia.
This localized and non-invasive therapeutic hypothermia successfully mitigated NIHL in rats. Our results show that mild hypothermia can be applied quickly and safely to the inner ear following noise exposure. We show that localized hypothermia after NIHL preserves residual hearing and rescues noise-induced synaptopathy over a period of months.
This study establishes a minimally-invasive therapeutic paradigm with a high potential for rapid translation to the clinic for long-term preservation of hearing health.
暴露于职业性或娱乐性高强度噪声会激活多个生物调节回路并损害耳蜗，导致听力敏感度发生永久性变化。目前，尚无有效的临床疗法可用于治疗或减轻噪声性听力损失（NIHL）。在此，我们描述了一种局部非侵入性治疗性低温疗法以及内耳靶向温度管理方法，用于预防NIHL。
我们开发了一种定制设计的冷却颈圈，在损伤后将内耳温度降低3-4°C，以实现轻度治疗性低温。
这种局部非侵入性治疗性低温成功减轻了大鼠的NIHL。我们的结果表明，噪声暴露后可快速、安全地对内耳进行轻度低温治疗。我们发现，NIHL后局部低温治疗可在数月内保留残余听力并挽救噪声引起的突触病变。
本研究建立了一种微创治疗模式，具有很高的潜力可迅速转化为临床应用，以长期保护听力健康。
