让染色质归位：先驱因子NeuroD1调节染色质状态以驱动细胞命运决定。
Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions.
作者信息
Glahs Alexander, Zinzen Robert P
机构信息
Laboratory of Systems Biology of Neural Tissue Differentiation, Berlin Institute of Medical Systems Biology (BIMSB) Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
出版信息
EMBO J. 2016 Jan 4;35(1):1-3. doi: 10.15252/embj.201593324. Epub 2015 Nov 13.
Abstract
Cell fate decisions require the deployment of distinct transcriptional programmes - how this is controlled and orchestrated is a key question from basic developmental biology to regenerative medicine. In this issue of The EMBO Journal, Pataskar and Jung et al (Pataskar et al, 2015) demonstrate how the transcription factor NeuroD1 acts genome-wide to elicit a specific neurogenic programme, including differentiation and migration. Much of that activity is due to NeuroD1 acting as a pioneer factor. NeuroD1 is able to bind its targets within repressive chromatin and can induce a more open chromatin state amenable to cell type‐specific regulation.
摘要
细胞命运决定需要部署不同的转录程序——从基础发育生物学到再生医学，如何控制和协调这一过程是一个关键问题。在本期《EMBO杂志》中，帕塔斯卡和荣格等人（帕塔斯卡等人，2015年）展示了转录因子NeuroD1如何在全基因组范围内发挥作用，引发特定的神经发生程序，包括分化和迁移。该活动的很大一部分归因于NeuroD1作为先驱因子的作用。NeuroD1能够在抑制性染色质中结合其靶标，并能诱导更开放的染色质状态，以适应细胞类型特异性调控。
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