1 Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, and Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine University of California at Davis , Davis, California.
Metab Syndr Relat Disord. 2014 May;12(4):227-30. doi: 10.1089/met.2014.0013. Epub 2014 Mar 4.
There is much data supporting a role for adipokines in both obesity and metabolic syndrome. Insulin resistance and low-grade inflammation are crucial in the genesis of both disorders. Although data suggest that the ratio of leptin/adiponectin correlates with insulin resistance and predicts cardiovascular disease (CVD), there is scanty data on the relationship between the retinol-binding protein-4 (RBP4)/adiponectin ratio with insulin resistance and inflammation. We tested the relationship of both these ratios with measures of insulin resistance and inflammation.
In 72 individuals, including controls and patients with metabolic syndrome, we calculated the homeostasis model assessment of insulin resistance (HOMA-IR) and assayed high-sensitivity C-reactive protein (hsCRP) and the adipokines, adiponectin, leptin, and RBP4.
Whereas both the leptin/adiponectin and RBP4/adiponectin ratios did not correlate with HOMA-IR, both correlated significantly with the prototypic biomarker of inflammation, hsCRP. Also in patients with metabolic syndrome following adjustment for adiposity, only the RBP4/adiponectin ratio was significantly increased.
Hence it appears that whereas both the leptin/adiponectin and RBP4/adiponectin ratios correlate with inflammation, only the RBP4/adiponectin ratio was significantly increased in metabolic syndrome and would be more useful to predict CVD, especially in metabolic syndrome.
有大量数据表明脂肪因子在肥胖和代谢综合征中都具有重要作用。胰岛素抵抗和低度炎症在这两种疾病的发生中起着关键作用。尽管数据表明瘦素/脂联素比值与胰岛素抵抗相关，并可预测心血管疾病（CVD），但关于视黄醇结合蛋白 4（RBP4）/脂联素比值与胰岛素抵抗和炎症之间关系的数据却很少。我们检测了这两个比值与胰岛素抵抗和炎症指标的关系。
在包括对照组和代谢综合征患者在内的 72 名个体中，我们计算了稳态模型评估的胰岛素抵抗（HOMA-IR），并检测了高敏 C 反应蛋白（hsCRP）和脂肪因子脂联素、瘦素和 RBP4。
尽管瘦素/脂联素和 RBP4/脂联素比值均与 HOMA-IR 无关，但与炎症的典型生物标志物 hsCRP 显著相关。在代谢综合征患者中，即使在调整了肥胖程度后，也只有 RBP4/脂联素比值显著升高。
因此，尽管瘦素/脂联素和 RBP4/脂联素比值均与炎症相关，但只有 RBP4/脂联素比值在代谢综合征中显著升高，并且更有助于预测 CVD，尤其是在代谢综合征中。
