School of Medicine School of Pharmacy, University of Mississippi School of St Dominic-Jackson Memorial Hospital, Mississippi.
School of Pharmacy, University of Mississippi.
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S662-8. doi: 10.1093/cid/civ739.
The etiology of cardiomyopathies are classified into 4 main groupings (dilated, hypertrophic, restrictive, and idiopathic) and can be mechanistically caused by myocarditis, conduction abnormalities, focal direct injury, or nutritional deficiency. Based on our review of this topic, evidence suggests that echinocandin-related cardiac dysfunction is a mitochondrial drug-induced disease caused by focal direct myocyte injury. With caspofungin or anidulafungin administration into the heart via central line, exposure is likely extreme enough to induce the acute toxicity. Chronic or low-dose exposure may lead to hypertrophic cardiomyopathy; however, only acute exposures have been explored to date.
心肌病的病因可分为 4 大主要类型（扩张型、肥厚型、限制型和特发性），其发病机制可能由心肌炎、传导异常、局灶性直接损伤或营养缺乏引起。根据我们对该主题的回顾，有证据表明棘白菌素类相关的心脏功能障碍是一种由局灶性直接心肌损伤引起的线粒体药物诱导性疾病。通过中心静脉给予卡泊芬净或阿尼芬净于心内给药，其暴露量很可能极高，足以诱发急性毒性。慢性或低剂量暴露可能导致肥厚型心肌病；然而，迄今为止仅探讨了急性暴露的情况。
