Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01114-18. Print 2018 Nov.
Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca concentration ([Ca]) after CAS treatment. Ca ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors.
最近的研究表明，危重症患者在使用卡泊芬净（CAS）治疗期间可能有发生血液动力学损伤的风险。我们目前的研究目的是研究 CAS 诱导心脏改变的背后机制。我们发现 CAS 处理后细胞内钙离子浓度 ([Ca]) 呈剂量依赖性增加。发现钙离子是从细胞内咖啡因敏感库中释放出来的，很可能是通过ryanodine 受体的激活。
