Parker James P, Ude Ziga, Marmion Celine J
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
Metallomics. 2016 Jan;8(1):43-60. doi: 10.1039/c5mt00181a.
Platinum drugs as anti-cancer therapeutics are held in extremely high regard. Despite their success, there are drawbacks associated with their use; their dose-limiting toxicity, their limited activity against an array of common cancers and patient resistance to Pt-based therapeutic regimes. Current investigations in medicinal inorganic chemistry strive to offset these shortcomings through selective targeting of Pt drugs and/or the development of Pt drugs with new or multiple modes of action. A comprehensive overview showcasing how liposomes, nanocapsules, polymers, dendrimers, nanoparticles and nanotubes may be employed as vehicles to selectively deliver cytotoxic Pt payloads to tumour cells is provided.
铂类药物作为抗癌治疗药物备受推崇。尽管取得了成功，但它们的使用存在一些缺点；它们的剂量限制性毒性、对一系列常见癌症的有限活性以及患者对铂类治疗方案的耐药性。药物无机化学领域目前的研究致力于通过选择性靶向铂类药物和/或开发具有新的或多种作用模式的铂类药物来弥补这些不足。本文全面概述了脂质体、纳米胶囊、聚合物、树枝状大分子、纳米颗粒和纳米管如何用作载体，将细胞毒性铂负载选择性地递送至肿瘤细胞。
