Klimova Blanka, Maresova Petra, Kuca Kamil
University Hospital Hradec Kralove Biomed Research Center, Hradec Kralove, Czech Republic.
Curr Alzheimer Res. 2016;13(11):1249-1258. doi: 10.2174/1567205013666151116142302.
Alzheimer's disease is a serious degenerative disease which is mainly typical of the developed countries. The prevalence percentage in Africa is only 2.6 %, whereas in America it is 6.5 % and in Western Europe 7.2 %. Overall, this disease affects 44 million people worldwide. With respect to the demographic development, a number of people suffering from Alzheimer's disease is expected in future. The key issue is not only the discovery of an effective medication, but also the early diagnosis, prevention and care about people with AD, as well as the provision of an equivalent rise of places in health and social institutions. Since the treatment of Alzheimer's disease (AD) imposes a severe economic and social burden, the main purpose of this study is to analyze and compare available non-pharmacological approaches to the prevention and treatment of patients with AD with special focus on their cognitive competences. In addition, the analysis also concentrates on the costs of pharmacological care in individual countries all over world. This is done by using Drummond's methodological approaches to direct and indirect costs. The analysis of non-pharmacological approaches is conducted on the basis of literature review of both clinical and review studies relevant for the research issue in the acknowledged databases and a comparison and evaluation of their findings.
阿尔茨海默病是一种严重的退行性疾病,主要在发达国家较为典型。非洲的患病率仅为2.6%,而美洲为6.5%,西欧为7.2%。总体而言,这种疾病在全球影响着4400万人。就人口发展而言,预计未来患阿尔茨海默病的人数会增加。关键问题不仅在于发现有效的药物,还在于早期诊断、预防以及对阿尔茨海默病患者的护理,以及在健康和社会机构中提供相应增加的床位。由于阿尔茨海默病(AD)的治疗带来了沉重的经济和社会负担,本研究的主要目的是分析和比较现有的非药物预防和治疗阿尔茨海默病患者的方法,特别关注其认知能力。此外,分析还集中于全球各个国家药物治疗的成本。这是通过使用德拉蒙德的方法来计算直接和间接成本来完成的。非药物方法的分析是基于对公认数据库中与研究问题相关的临床研究和综述研究的文献综述,以及对其研究结果的比较和评估。