Read Scott A, Collins Michael J, Vincent Stephen J
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6779-87. doi: 10.1167/iovs.14-15978.
The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood.
A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observational study. Axial eye growth was determined from measurements of ocular optical biometry collected at four study visits over an 18-month period. Each child's mean daily light exposure was derived from two periods (each 14 days long) of objective light exposure measurements from a wrist-worn light sensor.
Over the 18-month study period, a modest but statistically significant association between greater average daily light exposure and slower axial eye growth was observed (P = 0.047). Other significant predictors of axial eye growth in this population included children's refractive error group (P < 0.001), sex (P < 0.01), and age (P < 0.001). Categorized according to their objectively measured average daily light exposure and adjusting for potential confounders (age, sex, baseline axial length, parental myopia, nearwork, and physical activity), children experiencing low average daily light exposure (mean daily light exposure: 459 ± 117 lux, annual eye growth: 0.13 mm/y) exhibited significantly greater eye growth than children experiencing moderate (842 ± 109 lux, 0.060 mm/y), and high (1455 ± 317 lux, 0.065 mm/y) average daily light exposure levels (P = 0.01).
In this population of children, greater daily light exposure was associated with less axial eye growth over an 18-month period. These findings support the role of light exposure in the documented association between time spent outdoors and childhood myopia.
本研究旨在探讨客观测量的环境光暴露与儿童眼轴长度的纵向变化之间的关系。
共有101名10至15岁的儿童（41名近视儿童和60名非近视儿童）参与了这项前瞻性纵向观察研究。眼轴长度通过在18个月内的四次研究访视中收集的眼部光学生物测量数据来确定。每个孩子的平均每日光照暴露量来自于佩戴在手腕上的光传感器进行的两个为期14天的客观光照暴露测量时段。
在18个月的研究期间，观察到平均每日光照暴露量增加与眼轴生长减慢之间存在适度但具有统计学意义的关联（P = 0.047）。该人群中眼轴生长的其他显著预测因素包括儿童的屈光不正组（P < 0.001）、性别（P < 0.01）和年龄（P < 0.001）。根据客观测量的平均每日光照暴露量进行分类，并对潜在混杂因素（年龄、性别、基线眼轴长度、父母近视、近距离工作和身体活动）进行调整后，平均每日光照暴露量低的儿童（平均每日光照暴露量：459±117勒克斯，每年眼轴生长：0.13毫米/年）的眼轴生长明显高于平均每日光照暴露量中等（842±109勒克斯，0.060毫米/年）和高（1455±317勒克斯，0.065毫米/年）的儿童（P = 0.01）。
在这群儿童中，在18个月的时间里，每日光照暴露量增加与眼轴生长减少有关。这些发现支持了光照暴露在户外活动时间与儿童近视之间已记录的关联中的作用。
