4α-乙酰氧基阿米迪地醇——一种从巴西褐藻鹿角管栖藻中分离出的新型拒食多拉斯坦二萜。

4α-Acetoxyamijidictyol - A New Antifeeding Dolastane Diterpene from the Brazilian Brown Alga Canistrocarpus cervicornis.

作者信息

Miguel Bianco Éverson, Martins Francisco Thiago, Basílio Pinheiro Carlos, Bagueira de Vasconcellos Azeredo Rodrigo, Laneuville Teixeira Valéria, Crespo Pereira Renato

机构信息

Programa de Pós-graduação em Química, Departamento de Química, Fundação Universidade Regional de Blumenau, Campus 1, Bloco S, Victor Konder, CEP 89012-900, Blumenau, SC, Brazil, (phone: +55-47-33210615).

Programa de Pós-graduação em Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Baptista, Campus do Valonguinho, s/n, CEP 24020-150, Niterói, RJ, Brazil.

出版信息

Chem Biodivers. 2015 Nov;12(11):1665-77. doi: 10.1002/cbdv.201400410.

DOI:10.1002/cbdv.201400410

PMID:26567945

Abstract

Chemical investigation of the CH2 Cl2 crude extract from the brown alga Canistrocarpus cervicornis (Dictyotaceae) led to isolation of one new (1) and four previously reported dolastane diterpenes (2-5). Their structures were characterized by 1D- and 2D-NMR spectroscopic techniques, including a full single crystal X-ray diffraction analysis for 1, 2, and 4. In addition, the new structure 1 was assayed as chemical defense inhibiting the feeding by the sea urchin Lytechinus variegatus. This study constitutes an additional report broadening the known spectrum of action and defensive roles of secondary metabolites of the C. cervicornis and Dictyotales species.

摘要

对褐藻鹿角团扇藻（网地藻科）的二氯甲烷粗提物进行化学研究，分离得到了1个新的（1）和4个先前报道过的多拉烷二萜（2 - 5）。通过一维和二维核磁共振光谱技术对它们的结构进行了表征，其中包括对1、2和4进行了全单晶X射线衍射分析。此外，对新结构1进行了化学防御测定，以抑制海胆多色紫海胆的摄食。本研究构成了一份补充报告，拓宽了鹿角团扇藻和网地藻目物种次生代谢产物已知的作用谱和防御作用。