Fehér Erzsébet
Anatómiai, Szövet- és Fejlődéstani Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Tűzoltó u. 58., 1094.
Orv Hetil. 2015 Nov 22;156(47):1892-7. doi: 10.1556/650.2015.30300.
Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes. In hepatitis the number of both neuropeptide Y and substance P immunoreactive nerve fibres are increased, where the increase of neoropeptide Y is significant. A large number of lymphocytes and mast cells are also stained for neuropeptide Y and substance P. Very close associations (less than 1 µm) were observed between neuropeptide Y immunoreactive nerve fibres and immune cells stained also with neuropeptide Y. Some immune cells were also found to be immunoreactive for tumor necrosis factor-α and NF-κB. Some of the SP IR immunocells were also stained for TNF-α and nuclear factor kappaB. Based on these data it is hypothesized that neuropeptid Y and substance P released from nerve fibres and immune cells play a role in inflammation and elimination of inflammation in hepatitis.
神经肽Y和P物质被认为在免疫细胞功能以及炎症过程的放大或消除中发挥作用。在肝炎中，神经肽Y和P物质免疫反应性神经纤维的数量均增加，其中神经肽Y的增加显著。大量淋巴细胞和肥大细胞也被神经肽Y和P物质染色。观察到神经肽Y免疫反应性神经纤维与同样被神经肽Y染色的免疫细胞之间存在非常紧密的联系（小于1微米）。还发现一些免疫细胞对肿瘤坏死因子-α和核因子-κB有免疫反应性。一些P物质免疫反应性免疫细胞也被肿瘤坏死因子-α和核因子κB染色。基于这些数据，推测从神经纤维和免疫细胞释放的神经肽Y和P物质在肝炎的炎症和炎症消除中发挥作用。
