Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
Centre of Neurological and Metabolic Research, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
Front Immunol. 2020 Oct 6;11:580378. doi: 10.3389/fimmu.2020.580378. eCollection 2020.
Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in regulating a variety of biological processes, including food intake, energy metabolism, and emotional expression. However, emerging evidence points to NPY also as a critical transmitter between the nervous system and immune system, as well as a mediator produced and released by immune cells. and studies based on gene-editing techniques and specific NPY receptor agonists and antagonists have demonstrated that NPY is responsible for multifarious direct modulations on immune cells by acting on NPY receptors. Moreover, via the central or peripheral nervous system, NPY is closely connected to body temperature regulation, obesity development, glucose metabolism, and emotional expression, which are all immunomodulatory factors for the immune system. In this review, we focus on the direct role of NPY in immune cells and particularly discuss its indirect impact on the immune response.
神经肽 Y（NPY）广泛分布于神经系统中，参与调节多种生物过程，包括食物摄入、能量代谢和情绪表达。然而，新出现的证据表明，NPY 也是神经系统和免疫系统之间的关键递质，也是免疫细胞产生和释放的介质。基于基因编辑技术和特定 NPY 受体激动剂和拮抗剂的研究表明，NPY 通过作用于 NPY 受体对免疫细胞具有多种直接调节作用。此外，通过中枢或外周神经系统，NPY 与体温调节、肥胖发展、葡萄糖代谢和情绪表达密切相关，这些都是免疫系统的免疫调节因子。在这篇综述中，我们重点关注 NPY 在免疫细胞中的直接作用，并特别讨论其对免疫反应的间接影响。
