Jones Stephanie G, Benca Ruth M
Department of Psychiatry, Center for Sleep Medicine and Sleep Research, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
Department of Psychiatry, Center for Sleep Medicine and Sleep Research, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
Sleep Med Clin. 2015 Dec;10(4):481-93. doi: 10.1016/j.jsmc.2015.07.004. Epub 2015 Sep 16.
Evidence suggests that abnormalities in circadian rhythms might prove causally or pathophysiologically significant in psychiatric illness. The circadian regulation of hormonal and behavioral timekeeping processes is often altered in patients with major depression, bipolar disorder, and schizophrenia, and a susceptibility to rhythm instability may contribute to the functional impairment. For some patients, interventions that stabilize or resynchronize circadian rhythms prove therapeutically effective. Circadian disruption in the clinical profiles of most psychiatric illnesses and the treatment efficacy of chronobiological interventions suggest that attention to circadian phenotypes in a range of psychiatric disorders may help to uncover shared pathophysiologic mechanisms.
有证据表明，昼夜节律异常在精神疾病中可能具有因果关系或病理生理意义。在重度抑郁症、双相情感障碍和精神分裂症患者中，激素和行为计时过程的昼夜调节常常发生改变，节律不稳定的易感性可能导致功能障碍。对一些患者而言，稳定或重新同步昼夜节律的干预措施被证明具有治疗效果。大多数精神疾病临床特征中的昼夜节律紊乱以及时间生物学干预措施的治疗效果表明，关注一系列精神障碍中的昼夜表型可能有助于揭示共同的病理生理机制。
