Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, Via Vetoio, Coppito, 67100 L'Aquila, Italy.
National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital G. Mazzini, ASL 4 Teramo, Italy.
Curr Neuropharmacol. 2024;22(12):2016-2033. doi: 10.2174/1570159X22666240130091235.
Since discovering the glymphatic system, there has been a looming interest in exploring its relationship with psychiatric disorders. Recently, increasing evidence suggests an involvement of the glymphatic system in the pathophysiology of psychiatric disorders. However, clear data are still lacking. In this context, this rapid comprehensive PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) scoping review aims to identify and analyze current evidence about the relation between the glymphatic system and psychiatric disorders.
We conducted a comprehensive review of the literature and then proceeded to discuss the findings narratively. Tables were then constructed and articles were sorted according to authors, year, title, location of study, sample size, psychiatric disorder, the aim of the study, principal findings, implications.
Twenty papers were identified as eligible, among which 2 articles on Schizophrenia, 1 on Autism Spectrum Disorders, 2 on Depression, 1 on Depression and Trauma-related Disorders, 1 on Depression and Anxiety, 2 on Anxiety and Sleep Disorders, 8 on Sleep Disorders, 2 on Alcohol use disorder and 1 on Cocaine Use Disorder.
This review suggests a correlation between the glymphatic system and several psychiatric disorders: Schizophrenia, Depression, Anxiety Disorders, Sleep Disorders, Alcohol Use Disorder, Cocaine Use Disorder, Trauma-Related Disorders, and Autism Spectrum Disorders. Impairment of the glymphatic system could play a role in Trauma-Related Disorders, Alcohol Use Disorders, Cocaine Use Disorders, Sleep Disorders, Depression, and Autism Spectrum Disorders. It is important to implement research on this topic and adopt standardized markers and radio diagnostic tools.
自从发现脑淋巴系统以来，人们对探索其与精神疾病的关系产生了浓厚的兴趣。最近，越来越多的证据表明脑淋巴系统参与了精神疾病的病理生理学。然而，明确的数据仍然缺乏。在这种情况下，本快速全面的 PRISMA-ScR（系统评价和荟萃分析扩展的首选报告项目，用于范围综述）范围综述旨在确定和分析目前关于脑淋巴系统与精神疾病之间关系的证据。
我们对文献进行了全面的综述，然后进行了叙述性讨论。然后构建了表格，并根据作者、年份、标题、研究地点、样本大小、精神疾病、研究目的、主要发现、意义对文章进行了分类。
确定了 20 篇符合条件的论文，其中 2 篇关于精神分裂症，1 篇关于自闭症谱系障碍，2 篇关于抑郁症，1 篇关于抑郁症和创伤相关障碍，1 篇关于抑郁症和焦虑症，2 篇关于焦虑症和睡眠障碍，8 篇关于睡眠障碍，2 篇关于酒精使用障碍，1 篇关于可卡因使用障碍。
本综述表明脑淋巴系统与几种精神疾病之间存在相关性：精神分裂症、抑郁症、焦虑症、睡眠障碍、酒精使用障碍、可卡因使用障碍、创伤相关障碍和自闭症谱系障碍。脑淋巴系统的损伤可能在创伤相关障碍、酒精使用障碍、可卡因使用障碍、睡眠障碍、抑郁症和自闭症谱系障碍中发挥作用。重要的是要在这个主题上进行研究，并采用标准化的标志物和放射性诊断工具。
