Jin Miao, Spillane Dominic E M, Geraldes Carlos F G C, Williams Gareth R, Bligh S W Annie
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Dalton Trans. 2015 Dec 21;44(47):20728-34. doi: 10.1039/c5dt03433g. Epub 2015 Nov 16.
The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd(3+) diethylenetriaminepentaacetate and Gd(3+) diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5-18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd(3+) complexes in the intercalation compounds. The proton relaxivities of the Gd(3+) complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.
报道了两种基于钆的磁共振成像造影剂离子交换嵌入到羟基双盐（HDSs）中的情况。通过微波等离子体原子发射光谱法证实了嵌入后HDS晶格中存在钆（3+）二乙烯三胺五乙酸酯和钆（3+）二乙烯三胺五（亚甲基膦酸酯）配合物。通过X射线衍射研究了HDS-钆复合材料的结构方面，嵌入物的层间距为14.5-18.6 Å。红外光谱证实了嵌入化合物中存在与钆（3+）配合物相关的特征振动峰。与纯配合物溶液相比，负载钆（3+）配合物的复合材料的纵向弛豫率提高了2至5倍，横向弛豫率提高了高达10倍。这些数据表明，本文报道的新型复合材料可能是有效的MRI造影剂。
