Salado-Rasmussen Kirsten, Hoffmann Steen, Cowan Susan, Jensen Jørgen Skov, Benfield Thomas, Gerstoft Jan, Katzenstein Terese Lea
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Acta Derm Venereol. 2016 Aug 23;96(6):807-11. doi: 10.2340/00015555-2289.
Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
对同时感染艾滋病毒的患者，评估了口服多西环素或肌肉注射青霉素治疗梅毒的血清学反应。纳入了丹麦哥本哈根3家医院所有诊断为梅毒的艾滋病毒感染者。使用倾向评分调整的逻辑回归分析对与血清学结果相关的比值比（OR）及95%置信区间（CI）进行建模。总共202例患者接受了多西环素或肌肉注射青霉素治疗。12个月时，多西环素治疗的患者中有12例（15%）出现血清学失败，青霉素治疗的患者中有8例（17%）出现血清学失败（OR 0.78（95%CI 0.16 - 3.88），p = 0.76）。一期梅毒患者12个月时的血清学治愈率最高（100%），其次是二期梅毒患者（89%）、早期潜伏梅毒患者（71%）和晚期潜伏梅毒患者（67%）（p = 0.006）。总之，本研究为在治疗感染艾滋病毒人群的梅毒时使用多西环素作为一种治疗选择提供了证据。
