梅毒与人类免疫缺陷病毒1型（HIV-1）合并感染：对CD4 T细胞计数、HIV-1病毒载量及治疗反应的影响

Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response.

作者信息

Kofoed Kristian, Gerstoft Jan, Mathiesen Lars R, Benfield Thomas

机构信息

Clinical Research Unit, Hvidovre University Hospital, Copenhagen, Denmark.

出版信息

Sex Transm Dis. 2006 Mar;33(3):143-8. doi: 10.1097/01.olq.0000187262.56820.c0.

DOI:10.1097/01.olq.0000187262.56820.c0

PMID:16505739

Abstract

OBJECTIVES

To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection.

STUDY DESIGN

Cases of syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis.

RESULTS

Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm, P = 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm and -0.261 RNA log10 copies/ml, P = 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same.

CONCLUSION

Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis.

摘要

目的

评估人类免疫缺陷病毒（HIV）-1与梅毒合并感染对HIV核糖核酸（RNA）病毒载量、CD4细胞计数以及梅毒感染治疗后快速血浆反应素环状卡片试验（RPR）反应的影响。

研究设计

纳入哥本哈根1年内诊断出梅毒的HIV感染患者病例。在梅毒感染前、感染期间和感染后测量HIV-RNA、CD4细胞计数及RPR血清学指标。

结果

共纳入41例患者。一期和二期梅毒患者在感染期间CD4细胞计数显著下降（平均下降106个细胞/mm³，P = 0.03）。总体上，梅毒治疗与CD4细胞计数增加及HIV-RNA下降相关（平均增加66个细胞/mm³，HIV-RNA下降0.261 log10拷贝/ml，P = 0.02和0.04）。15例接受青霉素治疗和25例接受多西环素治疗患者的血清学反应率相同。