State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Biomater Sci. 2016 Feb;4(2):310-8. doi: 10.1039/c5bm00414d.
PLLA porous materials with high porosity were prepared by a gradual precipitation method and further modified by using different concentrations of gelatin aqueous solutions. Therefore, porous materials with different contents of gelatin coating were obtained. The micro morphology, crystallization, thermal performance, hydrophilicity and mechanical properties of the materials were evaluated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), thermogravimetric analysis (TGA), water uptake ability tests and compression tests. It was found that the modified materials were formed by the stacking of nanosheets. The materials can maintain more than 80% porosity, high water uptake abilities and fast water uptake rates after modification. The compressive moduli of the materials were significantly improved from the initial sample with a value of 0.57 MPa to 46.41 MPa with gelatin modification. Due to the high porosity of materials, interconnected pore structures, and good surface hydrophilicity, the materials were expected to be widely used in the field of tissue engineering scaffolds, especially for bone substitutes, mainly due to their tunable and excellent mechanical properties.
采用逐步沉淀法制备了具有高孔隙率的 PLLA 多孔材料，并进一步用不同浓度的明胶水溶液进行改性，得到了具有不同明胶涂层含量的多孔材料。通过扫描电子显微镜（SEM）、差示扫描量热法（DSC）、X 射线衍射（XRD）、热重分析（TGA）、吸水率测试和压缩测试对材料的微观形貌、结晶、热性能、亲水性和机械性能进行了评价。结果发现，改性材料是由纳米片堆叠形成的。改性后，材料的孔隙率仍保持在 80%以上，具有较高的吸水率和较快的吸水率。与初始样品（0.57 MPa）相比，材料的压缩模量通过明胶改性显著提高到 46.41 MPa。由于材料具有高孔隙率、相互连通的孔结构和良好的表面亲水性，预计它们将在组织工程支架领域得到广泛应用，特别是作为骨替代物，这主要是由于其可调谐的和优异的机械性能。
