Antal Zoltan, Sklar Charles A
Department of Pediatric Endocrinology, New York Presbyterian Hospital, Weill Cornell Medical College, 505 East 70 Street, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Endocrinol Metab Clin North Am. 2015 Dec;44(4):739-49. doi: 10.1016/j.ecl.2015.08.002. Epub 2015 Sep 15.
Reproductive health and fertility are of great importance to the increasing number of survivors of childhood cancer, approximately 70% of whom are estimated to be over 20 years old. This article reviews the various treatment exposures that have been associated with makers of gonadal injury and decreased fertility in childhood cancer survivors. Identifying risk factors that decrease fertility is essential in proper counseling and timely referral for interventions that may allow for future fertility in high-risk populations.
生殖健康和生育能力对越来越多的儿童癌症幸存者至关重要,据估计,其中约70%的人年龄超过20岁。本文综述了与儿童癌症幸存者性腺损伤和生育能力下降相关的各种治疗暴露情况。识别降低生育能力的风险因素对于在高危人群中进行适当的咨询和及时转诊以采取可能有助于未来生育的干预措施至关重要。