风湿性多肌痛的结局指标。一项系统评价。
Outcome Measures in Polymyalgia Rheumatica. A Systematic Review.
作者信息
Duarte Cátia, Ferreira Ricardo Jorge de Oliveira, Mackie Sarah Louise, Kirwan John Richard, Pereira da Silva José António
机构信息
From the Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra; Faculdade de Medicina, Universidade de Coimbra, Coimbra; and Health Sciences Research Unit: Nursing (UICISA:E), Coimbra, Portugal; Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, UK; and Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.C. Duarte, MD, Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, EPE; and Faculdade de Medicina, Universidade de Coimbra; R.J.O. Ferreira, RN, MSc, Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, EPE; and Health Sciences Research Unit: Nursing (UICISA:E); S.L. Mackie, BM, BCh, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds; J.R. Kirwan, PhD, University of Bristol, Academic Rheumatology Unit, Bristol Royal Infirmary; J.A. Pereira da Silva, PhD, Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, EPE; and Faculdade de Medicina, Universidade de Coimbra.
出版信息
J Rheumatol. 2015 Dec;42(12):2503-11. doi: 10.3899/jrheum.150515. Epub 2015 Nov 15.
OBJECTIVE
To identify the instruments used to assess polymyalgia rheumatica (PMR) in published studies.
METHODS
A systematic literature review of clinical trials and longitudinal observational studies related to PMR, published from 1970 to 2014, was carried out. All outcome and assessment instruments were extracted and categorized according to core areas and domains, as defined by the OMERACT (Outcome Measures in Rheumatology) Filter 2.0.
RESULTS
Thirty-five articles (3221 patients) were included: 12 randomized controlled trials (RCT); 3 nonrandomized trials; and 20 observational studies. More than 20 domains were identified, measured by 29 different instruments. The most frequently used measures were pain, morning stiffness, patient global assessment and physician global assessment, erythrocyte sedimentation rate, and C-reactive protein. The definition of outcomes varied considerably between studies.
CONCLUSION
The outcome measures and instruments used in PMR are numerous and diversely defined. The establishment of a core set of validated and standardized outcome measurements is needed.
目的
确定已发表研究中用于评估风湿性多肌痛（PMR）的工具。
方法
对1970年至2014年发表的与PMR相关的临床试验和纵向观察性研究进行系统的文献综述。提取所有结局和评估工具，并根据风湿病结局评估（OMERACT）Filter 2.0定义的核心领域和范畴进行分类。
结果
纳入35篇文章（3221例患者）：12项随机对照试验（RCT）；3项非随机试验；20项观察性研究。确定了20多个范畴，由29种不同工具进行测量。最常用的测量指标为疼痛、晨僵、患者整体评估、医生整体评估、红细胞沉降率和C反应蛋白。各研究之间结局的定义差异很大。
结论
PMR中使用的结局测量指标和工具众多且定义多样。需要建立一套经过验证和标准化的核心结局测量指标。
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