Ahmed Saad Bilal, Ahmad Saara, Pan Hanmei
Monash Health Rehabilitation and Aged Care Services, Melbourne, Australia.
Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.
Int Med Case Rep J. 2023 Dec 27;16:873-885. doi: 10.2147/IMCRJ.S440486. eCollection 2023.
Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of the elderly population that increases in incidence as age advances. It is characterised by the sudden or sub-acute onset of symptoms affecting the shoulder and pelvic girdles, often accompanied by constitutional symptoms. Due to the lack of consensual diagnostic criteria and specific laboratory or radiological investigations for PMR, its diagnosis can be very challenging, particularly because it can be mimicked or masked by other geriatric syndromes. PMR responds well to glucocorticoid treatment, but if left untreated, can lead to morbidity and poor quality of life. We present the case of an 87-year-old male who presented with a one-week history of localised pain in the left hip joint, later involving the contralateral hip. Previously able to ambulate unaided, his mobility was now severely impaired. Due to his Alzheimer's dementia and multiple comorbid geriatric conditions, extensive investigations were undertaken before a diagnosis of atypical PMR was reached. Treatment with a low dose of prednisolone led to a full recovery. This case highlights the inconsistency between an atypical presentation and the classic presentation of PMR and draws attention to the possibility of missed diagnosis in older, frail patients. Atypical symptomatology on top of cognitive impairment and language barriers can be easily overlooked and left untreated and could lead to severe adverse outcomes. Accurate diagnosis is crucial, as PMR is readily diagnosed, but the treatment with glucocorticoids, though generally straightforward, can pose challenges, particularly when dealing with polypharmacy and multiple coexisting health conditions.
风湿性多肌痛(PMR)是一种老年系统性炎症性疾病,发病率随年龄增长而增加。其特征为突然或亚急性发作的影响肩部和骨盆带的症状,常伴有全身症状。由于缺乏针对PMR的共识性诊断标准以及特定的实验室或影像学检查,其诊断极具挑战性,尤其是因为它可能被其他老年综合征所模仿或掩盖。PMR对糖皮质激素治疗反应良好,但如果不治疗,可能导致发病和生活质量下降。我们报告一例87岁男性病例,该患者有一周的左髋关节局部疼痛病史,随后累及对侧髋关节。他之前能够独立行走,现在活动能力严重受损。由于他患有阿尔茨海默病性痴呆和多种老年合并症,在诊断为非典型PMR之前进行了广泛的检查。低剂量泼尼松龙治疗使他完全康复。该病例突出了非典型表现与PMR经典表现之间的不一致,并提醒注意老年体弱患者漏诊的可能性。认知障碍和语言障碍之上的非典型症状很容易被忽视且得不到治疗,可能导致严重不良后果。准确诊断至关重要,因为PMR虽易于诊断,但糖皮质激素治疗虽通常简单直接,却可能带来挑战,尤其是在处理多重用药和多种并存健康状况时。