国际子痫前期基因研究：三大洲子痫前期的遗传学研究
InterPregGen: genetic studies of pre-eclampsia in three continents.
作者信息
Morgan Linda, McGinnis Ralph, Steinthorsdottir Valgerdur, Svyatova Gulnara, Zakhidova Nodira, Lee Wai Kwong, Iversen Ann-Charlotte, Magnus Per, Walker James, Casas Juan Pablo, Sultanov Saidazim, Laivuori Hannele
机构信息
School of Life Sciences, University of Nottingham, UK.
Wellcome Trust Sanger Institute, UK.
出版信息
Nor Epidemiol. 2014;24(1-2):141-146. doi: 10.5324/nje.v24i1-2.1815.
Abstract
Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and controls, with reliable supporting phenotypic data. The InterPregGen study has assembled a consortium of researchers from Europe, Central Asia and South America with the aim of elucidating the genetic architecture of pre-eclampsia. The MoBa collection is playing a vital role in this collaborative venture, which has the potential to provide new insights into the causes of pre-eclampsia, and provide a rational basis for novel approaches to prevention and treatment.
摘要
子痫前期是孕期孕产妇和胎儿死亡的主要原因。要确定易患子痫前期的基因变异，需要从患病母亲、婴儿及对照者那里收集大量DNA，并要有可靠的支持性表型数据。国际孕期遗传学研究（InterPregGen）汇集了来自欧洲、中亚和南美洲的研究人员组成联盟，旨在阐明子痫前期的遗传结构。挪威母亲、父亲和儿童队列研究（MoBa）数据集在这项合作项目中发挥着至关重要的作用，该项目有可能为子痫前期的病因提供新见解，并为预防和治疗的新方法提供合理依据。
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