Thomas Ryan M, Jobin Christian
Department of Surgery, North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA ; Department of Surgery, University of Florida, Gainesville, FL 32611, USA.
Department of Medicine and Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, 32611, USA.
Trends Cancer. 2015 Sep 1;1(1):24-35. doi: 10.1016/j.trecan.2015.07.005.
Investigations focused on the interplay between the human microbiome and cancer development, herein termed the 'oncobiome', have been growing at a rapid rate. However, these studies to date have primarily demonstrated associative relationships rather than causative ones. We pose the question of whether this emerging field of research is a 'mirage' without a clear picture, or truly represents a paradigm shift for cancer research. We propose the necessary steps needed to answer crucial questions and push the field forward to bring the mirage into a tangible reality.
专注于人类微生物组与癌症发展之间相互作用（本文称之为“肿瘤微生物组”）的研究一直在迅速增加。然而，迄今为止这些研究主要证明的是关联关系而非因果关系。我们提出这样一个问题：这个新兴的研究领域究竟是没有清晰图景的“海市蜃楼”，还是真的代表了癌症研究的范式转变。我们提出了回答关键问题并推动该领域向前发展以使这一“海市蜃楼”成为切实现实所需的必要步骤。
