Gibbs Raisha J, Chambers Adam C, Hill Darryl J
University of Bristol, Bristol, UK.
Eur J Clin Invest. 2024 Dec;54 Suppl 2(Suppl 2):e14353. doi: 10.1111/eci.14353.
The Fusobacterium genus comprises Gram-negative, obligate anaerobic bacteria that typically reside in the periodontium of the oral cavity, gastrointestinal tract, and female genital tract. The association of Fusobacterial spp. with colorectal tumours is widely accepted, with further evidence that this pathogen may also be implicated in the development of other malignancies. Fusobacterial spp. influence malignant cell behaviours and the tumour microenvironment in various ways, which can be related to the multiple surface adhesins expressed. These adhesins include Fap2 (fibroblast-activated protein 2), CpbF (CEACAM binding protein of Fusobacteria), FadA (Fusobacterium adhesin A) and FomA (Fusobacterial outer membrane protein A). This review outlines the influence of Fusobacteria in promoting cancer initiation and progression, impacts of therapeutic outcomes and discusses potential therapeutic interventions where appropriate.
梭杆菌属包括革兰氏阴性专性厌氧菌，通常存在于口腔、胃肠道和女性生殖道的牙周组织中。梭杆菌属与结直肠癌的关联已被广泛认可，并有进一步证据表明这种病原体可能也与其他恶性肿瘤的发生有关。梭杆菌属通过多种方式影响恶性细胞行为和肿瘤微环境，这可能与所表达的多种表面黏附素有关。这些黏附素包括Fap2（成纤维细胞激活蛋白2）、CpbF（梭杆菌的癌胚抗原相关细胞黏附分子结合蛋白）、FadA（梭杆菌黏附素A）和FomA（梭杆菌外膜蛋白A）。本综述概述了梭杆菌在促进癌症起始和进展方面的影响、治疗结果的影响，并在适当情况下讨论了潜在的治疗干预措施。
