Guys and St Thomas NHS Trust, Kings College London, London, United Kingdom.
University East Anglia, Norwich and James Paget Hospital, Great Yarmouth, United Kingdom.
Rhinology. 2016 Mar;54(1):20-6. doi: 10.4193/Rhino15.199.
Promoting the assessment of health interventions using outcomes that matter to patients and practitioners is a key principle of Cochrane. Cochrane UK therefore commissioned the OMIPP project: Outcomes that are Most Important for Patients, Public and Practitioners to identify the outcomes they felt most important and should be evaluated in Cochrane reviews of health interventions for Chronic Rhinosinusitis (CRS).
Using direct emailing, social media and printed cards, an online survey was distributed to a wide range of people involved in the care of patients with CRS. Patients and practitioners were asked to list the 3 outcomes from treatments most important to them. Responses were analysed through development of a thematic framework based on the data.
Two hundred and thirty-five people completed the survey; 155 practitioners and 80 patients. Respondents provided 653 suggestions of important outcomes. 73% concerned symptoms of CRS, (nasal discharge or drip, facial pain, nasal blockage, headache, impaired sense of smell, congestion and breathing difficulties); 9% concerned quality of life, 4% reducing the need for further treatment and 4% side effects of treatment. Objective measurements of disease formed only 3% of responses. There was high level of agreement between patients and practitioners. Of 10 current Cochrane reviews on CRS, 9 include symptomatic outcomes identified by our survey as most important to patients and healthcare practitioners.
We have identified outcomes that both patients and their doctors consider should be included in reviews evaluating treatments of rhinosinusitis. We recommend that primary outcomes in future reviews focus on symptom-based outcomes. The ability to extract these data from relevant trials is dependent upon their inclusion in trials, and so it is important that building on this work a core outcome set for rhinosinusitis research is developed.
促进评估对患者和从业者重要的健康干预措施是 Cochrane 的一个关键原则。因此，Cochrane UK 委托 OMIPP 项目：患者、公众和从业者最关注的结果，以确定他们认为在慢性鼻-鼻窦炎（CRS）健康干预措施的 Cochrane 评价中最重要的、应进行评估的结果。
通过直接电子邮件、社交媒体和印刷卡片，向广泛参与 CRS 患者护理的人群分发了在线调查。患者和从业者被要求列出对他们最重要的三种治疗结果。通过基于数据的主题框架的发展来分析响应。
235 人完成了调查；155 名从业者和 80 名患者。受访者提供了 653 个重要结果的建议。73%的建议与 CRS 的症状有关（鼻腔分泌物或滴注、面部疼痛、鼻腔阻塞、头痛、嗅觉受损、鼻塞和呼吸困难）；9%的建议与生活质量有关，4%的建议与减少进一步治疗的需要有关，4%的建议与治疗的副作用有关。疾病的客观测量仅占响应的 3%。患者和从业者之间存在高度一致。在 10 项关于 CRS 的当前 Cochrane 评价中，9 项包括我们的调查确定的患者和医疗保健从业者认为最重要的症状性结果。
我们已经确定了患者及其医生认为应包括在评估治疗鼻窦炎的评价中的结果。我们建议，未来的评价中主要结果应集中在基于症状的结果上。从相关试验中提取这些数据的能力取决于它们在试验中的纳入情况，因此，重要的是在这项工作的基础上，为鼻窦炎研究制定一个核心结果集。
