Ting Fiona, Hopkins Claire
1ENT Department, Guy's Hospital, Great Maze Pond, London, SE1 9RT UK.
2King's College London, London, UK.
Curr Otorhinolaryngol Rep. 2018;6(3):271-275. doi: 10.1007/s40136-018-0215-3. Epub 2018 Aug 16.
Chronic rhinosinusitis (CRS) has a significant impact on the quality of life of patients and is a high cost burden to both society and patients. There is a variety of objective and subjective outcome measures that exist to assess the effectiveness of interventions. We aim to review current outcome measures available.
Traditionally, results have focused on objective measures, however, subjective outcome measures are gaining traction as being more important. Outcome measures in chronic rhinosinusitis are currently heterogeneous, thus limiting the impact of meta-analysis of past trial results. The development of a core outcome set may standardize the reporting of outcomes in chronic rhinosinusitis.
We outline the outcome measures currently available and discuss a proposed core outcome set that may facilitate further value of research on interventions for CRS in adults.
慢性鼻-鼻窦炎（CRS）对患者生活质量有重大影响，给社会和患者都带来高昂的成本负担。有多种客观和主观的结局指标可用于评估干预措施的有效性。我们旨在综述当前可用的结局指标。
传统上，结果侧重于客观指标，然而，主观结局指标正越来越受到重视，因为其更为重要。慢性鼻-鼻窦炎的结局指标目前存在异质性，因此限制了对过去试验结果进行荟萃分析的影响。核心结局集的制定可能会使慢性鼻-鼻窦炎结局的报告标准化。
我们概述了目前可用的结局指标，并讨论了一个拟议的核心结局集，该核心结局集可能有助于进一步提升针对成人CRS干预措施研究的价值。
