Ubukata Shiho, Ueda Keita, Sugihara Genichi, Yassin Walid, Aso Toshihiko, Fukuyama Hidenao, Murai Toshiya
From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
J Neuropsychiatry Clin Neurosci. 2016 Spring;28(2):97-103. doi: 10.1176/appi.neuropsych.15070159. Epub 2015 Nov 16.
Diffuse axonal injury is a major form of traumatic brain injury. Neuropsychological assessments and high-resolution structural MRI were conducted using T1-weighted and diffusion tensor imaging. This study included 10 patients with diffuse axonal injury (all men, mean age 30.8±10.5 years) and 12 age- and sex-matched normal control participants. Patients with diffuse axonal injury had widespread volume reductions and lower fractional anisotropy in the corpus callosum (CC) compared with controls. Furthermore, cognitive processing speed was associated with reductions in white matter volume and fractional anisotropy in the CC. These findings suggest that CC pathology may be a potential surrogate marker of the cognitive deficits in these patients.
弥漫性轴索损伤是创伤性脑损伤的主要形式。使用T1加权成像和扩散张量成像进行了神经心理学评估和高分辨率结构磁共振成像。本研究纳入了10例弥漫性轴索损伤患者（均为男性，平均年龄30.8±10.5岁）和12名年龄及性别匹配的正常对照参与者。与对照组相比，弥漫性轴索损伤患者胼胝体（CC）的体积普遍减小且各向异性分数较低。此外，认知加工速度与CC中白质体积减少和各向异性分数降低有关。这些发现表明，CC病理可能是这些患者认知缺陷的潜在替代标志物。
