1Fuller Graduate School of Psychology,Travis Research Institute,Pasadena,California.
2California Institute of Technology,Division of Humanities and Social Sciences,Pasadena,California.
J Int Neuropsychol Soc. 2019 Mar;25(3):324-330. doi: 10.1017/S135561771800111X. Epub 2019 Jan 29.
Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum. Because the disorder can only be firmly diagnosed via neuroradiology, it has a short research history, and only recently has the cognitive syndrome become clear.
Our purpose is to review the primary deficits in AgCC that constitute the core syndrome.
The cores syndrome includes: (1) reduced interhemispheric transfer of sensory-motor information; (2) reduced cognitive processing speed; and (3) deficits in complex reasoning and novel problem-solving. These domains do not appear to reflect different neuroanatomical abnormalities, but rather different domains of expression of reduced interhemispheric communication from callosal absence.
These core deficits are expressed across various domains of cognitive, behavioral, and social functioning. The impact of these deficits varies across development and may be moderated by individual factors such as co-occurrence of other neurodevelopmental conditions, general intellectual capacity, and environmental support. (JINS, 2019, 25, 324-330).
胼胝体发育不全（AgCC）涉及胼胝体全部或部分缺失。由于该疾病只能通过神经影像学来明确诊断，因此其研究历史较短，直到最近才明确其认知综合征。
我们的目的是回顾构成核心综合征的 AgCC 的主要缺陷。
核心综合征包括：（1）感觉运动信息的大脑两半球间传递减少；（2）认知加工速度降低；（3）复杂推理和新问题解决能力缺陷。这些领域似乎并不反映不同的神经解剖异常，而是反映了胼胝体缺失导致的大脑两半球间通讯减少的不同表达领域。
这些核心缺陷在认知、行为和社会功能的各个领域都有表现。这些缺陷的影响因发展阶段而异，可能受到个体因素的调节，如其他神经发育状况的同时发生、一般智力水平和环境支持。（JINS，2019，25，324-330）。
