Leonard Maureen M, Camhi Stephanie, Huedo-Medina Tania B, Fasano Alessio
Center for Celiac Research, Massachusetts General Hospital for Children, Boston, MA 02114, USA.
Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA.
Nutrients. 2015 Nov 11;7(11):9325-36. doi: 10.3390/nu7115470.
In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD). Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli. Many environmental factors known to influence the composition of the intestinal microbiota are also suggested to play a role in the development of CD. These include birthing delivery mode, infant feeding, and antibiotic use. To date no large-scale longitudinal studies have defined if and how gut microbiota composition and metabolomic profiles may influence the loss of gluten tolerance and subsequent onset of CD in genetically-susceptible individuals. Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.
过去人们认为，遗传易感性和接触麸质是发生乳糜泻（CD）的必要且充分条件。然而，最近的研究表明，由于其他环境刺激，麸质耐受性的丧失可能在生命中的任何时候发生。许多已知会影响肠道微生物群组成的环境因素也被认为在CD的发展中起作用。这些因素包括分娩方式、婴儿喂养和抗生素使用。迄今为止，尚无大规模纵向研究确定肠道微生物群组成和代谢组学特征是否以及如何影响遗传易感个体中麸质耐受性的丧失和随后CD的发病。在此，我们描述了一项针对有CD风险婴儿的前瞻性、多中心、纵向研究，该研究将采用基础研究和应用研究相结合的方法，以深入了解肠道微生物群作为一个可能在自身免疫性疾病发病早期步骤中起关键作用的额外因素所发挥的作用。
