染色质修饰和肥大细胞迁移在紫外线诱导的免疫抑制中的作用：一个表观遗传学谜题的一部分。
Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle.
机构信息
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
J Invest Dermatol. 2015 Dec;135(12):2911-2913. doi: 10.1038/jid.2015.379.
The migration of dermal mast cells to skin-draining lymph nodes is a key step in UV-induced immunosuppression. Examining the effects of platelet-activating factor (PAF), a phospholipid mediator secreted by keratinocytes following UV exposure, on mast cells, Damiani et al. demonstrate that increased expression of CXCR4 is associated with increased histone acetylation at the promoter of this chemokine receptor gene.
真皮肥大细胞向皮肤引流淋巴结的迁移是 UV 诱导免疫抑制的关键步骤。达米亚尼等人研究了血小板激活因子（PAF）的作用，PAF 是角质形成细胞在 UV 暴露后分泌的一种磷脂介质，对肥大细胞的影响。他们证明，CXCR4 的表达增加与该趋化因子受体基因启动子处组蛋白乙酰化的增加有关。
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