Van der Walt J G
Department of Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
J S Afr Vet Assoc. 1989 Mar;60(1):65-8.
The biochemical reactions leading to the formation of eicosanoid compounds are reviewed. Arachidonic acid and similar homologous polyunsaturated acids are shown to be important precursors of these compounds. The partitioning of precursors between the cyclo-oxygenase and lipoxygenase enzyme systems leads to the prostanoid/thromboxane/prostacyclin and leukotriene families groups are reviewed. The mechanism of action of the prostacyclin group is briefly discussed.
本文综述了导致类二十烷酸化合物形成的生化反应。花生四烯酸和类似的同系多不饱和酸被证明是这些化合物的重要前体。本文还综述了前体在环氧化酶和脂氧化酶系统之间的分配如何导致前列腺素/血栓素/前列环素和白三烯家族的形成。本文简要讨论了前列环素类的作用机制。
