Amsterdam Daniel
a Departments of Microbiology and Immunology, Medicine, and Pathology , School of Medicine and Biomedical Sciences, University at Buffalo, and Department of Laboratory Medicine, Erie County Medical Center , Buffalo, NY , USA.
Immunol Invest. 2015;44(8):719-30. doi: 10.3109/08820139.2015.1096680.
Since the onset of the AIDS epidemic over 35 years ago, attempts at immunologic manipulation to develop preventative and therapeutic approaches to HIV infection have been the subject of intense focus by the scientific community. New tactics such as latency reveal agents and immune interventions with engineered and directed monoclonal antibodies, as well as vaccines for prevention and treatment are among the strategies addressed in this review.
自35多年前艾滋病流行以来,通过免疫调控来开发预防和治疗HIV感染方法的尝试一直是科学界密切关注的焦点。本综述讨论的策略包括潜伏激活剂、工程化和定向单克隆抗体的免疫干预等新策略,以及用于预防和治疗的疫苗。