Ostrov Barbara E
a Department of Pediatrics , Pediatric Rheumatology and Rheumatology, Pediatrician-in-Chief of Penn State Hershey Children's Hospital , Hershey , PA , USA.
Immunol Invest. 2015;44(8):777-802. doi: 10.3109/08820139.2015.1093912.
In recent decades, innovative strategies to treat patients with inflammatory, immunologically based diseases have advanced in concert with our increased understanding of molecular immunology. Recognition of the spectrum and pathophysiology of autoimmune and autoinflammatory disorders has allowed for the development of cutting-edge therapies for such patients. In this review, key immunotherapeutic approaches for treating inflammatory autoimmune disorders, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as well as genetic autoinflammatory diseases, such as cryopyrin associated periodic syndromes, are addressed. Indications, risks and additional considerations in the use of these agents are reviewed.
近几十年来，随着我们对分子免疫学的深入了解，治疗炎症性、免疫性疾病患者的创新策略也不断发展。对自身免疫性和自身炎症性疾病的范围及病理生理学的认识，使得针对此类患者的前沿疗法得以开发。在本综述中，将探讨治疗炎症性自身免疫性疾病（如类风湿关节炎（RA）和系统性红斑狼疮（SLE））以及遗传性自身炎症性疾病（如冷吡啉相关周期性综合征）的关键免疫治疗方法。还将综述这些药物的适应症、风险及其他注意事项。
