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包括免疫疗法在内的器官特异性自身免疫性疾病概述

An Overview of Organ-Specific Autoimmune Diseases Including Immunotherapy.

作者信息

Mastrandrea Lucy D

机构信息

a Division of Pediatric Endocrinology, Department of Pediatrics , School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, NY , USA.

出版信息

Immunol Invest. 2015;44(8):803-16. doi: 10.3109/08820139.2015.1099409.

Abstract

A significant number of individuals are affected by autoimmune diseases, which are caused by aberrant recognition of self by the immune system. A wide variety of cells and organ systems are targets of pathologic activation of the immune mediators. Effective and safe therapies aimed at managing the chronic inflammatory aspect of many autoimmune diseases remain elusive. This review will focus on the available interventions and discuss the future of the field to prevent organ destruction by the autoimmune process.

摘要

相当多的人受到自身免疫性疾病的影响,这些疾病是由免疫系统对自身的异常识别引起的。多种细胞和器官系统是免疫介质病理性激活的目标。旨在控制许多自身免疫性疾病慢性炎症方面的有效且安全的疗法仍然难以实现。本综述将聚焦于现有的干预措施,并讨论该领域预防自身免疫过程导致器官破坏的未来发展。

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